[CAS NO. 376616-73-8] ZQ-16
PRODUCTS SPECIFICATIONS [376616-73-8]
DESCRIPTION [376616-73-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 228.31 |
| Molecular Formula | C10H16N2O2S |
| SMILES | O=C1NC(SCCCCCC)=NC(O)=C1 |
Summary
In Vitro
ZQ-16 induces calcium response in a dose-dependent manner, with an EC
50
value of 0.213 μM
[1]
.
ZQ-16 also induces dose-dependent reduction of Forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84 with an EC
50
value of 0.134 μM
[1]
.
ZQ-16 (10 μM; 5 min) also induces phosphorylation of ERK1/2 in GPR84-expressing HEK293 cells
[1]
.
ZQ-16 induces GPR84 desensitization, internalization, and β-arrestin2 recruitment. ZQ-16 induced a dose-dependent recruitment of β-Arrestin2 towards GPR84 in HEK293 cells expressing both proteins with an EC
50
value of 0.597 μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | HEK293 cells |
| Concentration: | 10 μM |
| Incubation Time: | 5 min |
| Result: | Induced phosphorylation of ERK1/2. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.