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[CAS NO. 38183-03-8] 7,8-Dihydroxyflavone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W013372 |
| Brand: | MCE |
| CAS: | 38183-03-8 |
Overview
| MDL | MFCD00006836 |
|---|---|
| Molecular Weight | 254.24 |
| Molecular Formula | C15H10O4 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13 |
10 Publications Citing Use of MCE
- [1]Mol Psychiatry. 2021 Oct 12.
- [2]Ecotoxicol Environ Saf. 2022 Nov 21;248:114307.
- [3]J Agric Food Chem. 2021 Nov 4.
- [4]Eur J Pharmacol. 2022 Nov 22;175420.
- [5]Drug Des Dev Ther. 2021 Mar 30;15:1409-1422.
- [6]Int J Med Sci. 2022 Jan 1;19(1):13-24.
- [7]Int J Med Sci. 2022; 19(1):13-24.
- [8]PeerJ. 2022 Feb 15;10:e12886.
- [9]Sleep Breath. 2021 May 15.
- [10]Evid Based Complement Alternat Med. 2022 Feb 14;2022:2497430.
Summary
IC50 & Target
TrkB [1]
In Vitro
7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease [1] .
Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 393.33 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL |
| 5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL |
Synonyms
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