[CAS NO. 382-45-6] Adrenosterone
PRODUCTS SPECIFICATIONS [382-45-6]
DESCRIPTION [382-45-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 300.39 |
| Molecular Formula | C19H24O3 |
| SMILES | C[C@@]([C@](CC1)([H])[C@]2([H])CCC3=CC(CC[C@]3(C)[C@@]2([H])C4=O)=O)(C4)C1=O |
Summary
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells [1] [2] [3] .
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells)
[1]
.
Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 83.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3290 mL | 16.6450 mL | 33.2901 mL |
| 5 mM | 0.6658 mL | 3.3290 mL | 6.6580 mL |
| 10 mM | 0.3329 mL | 1.6645 mL | 3.3290 mL |
References
- [1] Joji Nakayama, et al. A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial-Mesenchymal Transition and Metastatic Dissemination. Mol Cancer Res. 2020 Mar;18(3):477-487.
- [2] Brooker L, et al. Carbon isotope ratio analysis of endogenous glucocorticoid urinary metabolites after cortisone acetate andadrenosterone administration for doping control. Drug Test Anal. 2012 Dec;4(12):951-61.
- [3] Choudhary MI, et al. Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans. Steroids. 2007 Dec;72(14):923-9.
Synonyms