[CAS NO. 388592-44-7] CK-869

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PRODUCTS SPECIFICATIONS [388592-44-7]

Catalog

HY-16927

Brand

MCE

CAS

388592-44-7

DESCRIPTION [388592-44-7]

Overview

MDL	MFCD01844129
Molecular Weight	394.28
Molecular Formula	C17H16BrNO3S
SMILES	O=C1N(C2=CC=C(OC)C=C2OC)C(C3=CC=CC(Br)=C3)SC1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Cell Rep. 2021 Jul 6;36(1):109318.

Summary

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC ₅₀ of 7 μM.

IC50 & Target

IC50: 7 μM (ARP2/3) ^[1] .

In Vitro

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC ₅₀ of 7 μM ^[1] . CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 63.41 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5363 mL	12.6813 mL	25.3627 mL
5 mM	0.5073 mL	2.5363 mL	5.0725 mL
10 mM	0.2536 mL	1.2681 mL	2.5363 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.34 mM); Suspended solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

* All of the co-solvents are available by MCE.