[CAS NO. 39800-16-3] 4-Hydroperoxycyclophosphamide

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [39800-16-3]

Catalog

HY-117433

Brand

MCE

CAS

39800-16-3

DESCRIPTION [39800-16-3]

Overview

MDL	-
Molecular Weight	293.08
Molecular Formula	C7H15Cl2N2O4P
SMILES	O=P1(OCCC(N1)OO)N(CCCl)CCCl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]AfricArXiv Preprints. 2212.

Summary

4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS) . 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 170.60 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4120 mL	17.0602 mL	34.1204 mL
5 mM	0.6824 mL	3.4120 mL	6.8241 mL
10 mM	0.3412 mL	1.7060 mL	3.4120 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (8.53 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

Synonyms

Hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl

Hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl, P-oxide

2H-1,3,2-Oxazaphosphorine, hydroperoxide deriv.

2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide

4-Hydroperoxycyclophosphamide

4-Hydroperoxycyclofosfamide

Asta 6496