[CAS NO. 39809-25-1] Penciclovir
PRODUCTS SPECIFICATIONS [39809-25-1]
DESCRIPTION [39809-25-1]
Overview
| MDL | MFCD00866931 |
|---|---|
| Molecular Weight | 253.26 |
| Molecular Formula | C10H15N5O3 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2CCC(CO)CO |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
HSV-1 0.5 μg/mL (EC 50 ) |
HSV-2 0.8 μg/mL (EC 50 ) |
In Vitro
Penciclovir (0-100 µg/ml) shows anti-herpesvirus activity with EC
50
s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively
[1]
.
Penciclovir (0-100 µg/ml) shows no-toxic to uninfected human cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells |
| Concentration: | 0-100 µg/ml |
| Incubation Time: | |
| Result: | Showed no-toxic with IC 50 s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively. |
In Vivo
Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Three-week-old female Balb/c mice [2] |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; daily for 5 days |
| Result: | Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00820534 | Novartis |
Cold Sore
|
December 2008 | Phase 4 |
| NCT01257074 | EMS |
Herpes Labialis
|
February 2012 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 98.71 mM ; Need ultrasonic)
H 2 O : 2 mg/mL ( 7.90 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9485 mL | 19.7426 mL | 39.4851 mL |
| 5 mM | 0.7897 mL | 3.9485 mL | 7.8970 mL |
| 10 mM | 0.3949 mL | 1.9743 mL | 3.9485 mL |
References
- [1] M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11.
- [2] de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89.
Synonyms