[CAS NO. 403848-57-7] Caspase-9 Inhibitor III
PRODUCTS SPECIFICATIONS [403848-57-7]
DESCRIPTION [403848-57-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 587.02 |
| Molecular Formula | C24H35ClN6O9 |
| SMILES | CC(C)C[C@H](NC(C)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(O)=O)C(CCl)=O)=O)CC1=CN=CN1)=O)=O |
Summary
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury [1] .
IC50 & Target
|
Caspase-9 |
In Vitro
Caspase-9 Inhibitor III (0.07-0.105 μM; perfused for 10 min) significantly attenuates I/R induced increase in infarct size, release of lactate dehydrogenase and creatine kinase in the coronary effluent, and apoptotic index of isolated rat heart
[1]
.
Caspase-9 Inhibitor III (30 μM) inhibits troponin I proteolysis induced by MMP-2
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Sodhi RK, et, al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch Pharm Res. 2009 Jul;32(7):1037-43.
- [2] Castro MM, et, al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem Pharmacol. 2013 Aug 15;86(4):469-75.