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[CAS NO. 415697-08-4] SN 6
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-107658 |
| Brand: | MCE |
| CAS: | 415697-08-4 |
Overview
| MDL | MFCD06798326 |
|---|---|
| Molecular Weight | 402.46 |
| Molecular Formula | C20H22N2O5S |
| SMILES | CCOC(C(CS1)NC1CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)=O |
4 Publications Citing Use of MCE
Summary
SN 6 is a selective Na + /Ca 2+ exchanger (NCX) inhibitor, and inhibits 45 Ca 2+ uptake by NCX1, NCX2, and NCX3, with IC 50 s of 2.9, 16, and 8.6 μM, respectively.
IC50 & Target
IC50：2.9 μM (NCX1), 16 μM (NCX2), 8.6 μM (NCX3) [1]
In Vitro
SN 6 is a selective Na + /Ca 2+ exchanger inhibitor, which inhibits the initial rate of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC 50 of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na + i -dependent 45 Ca 2+ uptake into Na + -loaded sarcolemmal vesicles in a dose dependent manner (IC 50 , 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants [1] . SN 6 (1-30 μM) suppresses the bidirectional outward and inward I NCX in a concentration-dependent manner, with IC 50 values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (I NCX ) in a [Na + ]i concentration-dependent manner, with IC 50 values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na + ]i, respectively [2] . SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC 50 value of 0.63 ± 0.15 μM in NCX1 transfectants [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 155.29 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4847 mL | 12.4236 mL | 24.8472 mL |
| 5 mM | 0.4969 mL | 2.4847 mL | 4.9694 mL |
| 10 mM | 0.2485 mL | 1.2424 mL | 2.4847 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: 2.08 mg/mL (5.17 mM); Clear solution; Need warming
References
- [1] Iwamoto T, et al. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol. 2004 Jul;66(1):45-55
- [2] Niu CF, et al. Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Ann N Y Acad Sci. 2007 Mar;1099:534-9.
- [3] Kita S, et al. Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor. Ann N Y Acad Sci. 2007 Mar;1099:529-33.
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