[CAS NO. 43077-30-1] DPO-1
PRODUCTS SPECIFICATIONS [43077-30-1]
DESCRIPTION [43077-30-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 340.44 |
| Molecular Formula | C22H29OP |
| SMILES | CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C |
Summary
DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype K v 1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 10 mg/mL ( 29.37 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9374 mL | 14.6869 mL | 29.3738 mL |
| 5 mM | 0.5875 mL | 2.9374 mL | 5.8748 mL |
| 10 mM | 0.2937 mL | 1.4687 mL | 2.9374 mL |
References
- [1] Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63.
- [2] Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7.
Synonyms