[CAS NO. 433249-94-6] TRAF-STOP inhibitor 6877002
PRODUCTS SPECIFICATIONS [433249-94-6]
DESCRIPTION [433249-94-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 251.32 |
| Molecular Formula | C17H17NO |
| SMILES | O=C(C1=CC=CC=C1)/C=C/NC2=C(C=CC(C)=C2)C |
Summary
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1 [1] . TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques [2] .
IC50 & Target
CD40-TRAF6 interaction; NF-κB
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 497.37 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9790 mL | 19.8950 mL | 39.7899 mL |
| 5 mM | 0.7958 mL | 3.9790 mL | 7.9580 mL |
| 10 mM | 0.3979 mL | 1.9895 mL | 3.9790 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (8.28 mM); Clear solution