[CAS NO. 4335-12-0] Toddaculin
PRODUCTS SPECIFICATIONS [4335-12-0]
DESCRIPTION [4335-12-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 274.31 |
| Molecular Formula | C16H18O4 |
| SMILES | O=C1C=CC2=C(OC)C(C/C=C(C)\C)=C(OC)C=C2O1 |
Summary
In Vitro
Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC
50
of 51.38 μM
[1]
.
Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL ( 182.28 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6455 mL | 18.2276 mL | 36.4551 mL |
| 5 mM | 0.7291 mL | 3.6455 mL | 7.2910 mL |
| 10 mM | 0.3646 mL | 1.8228 mL | 3.6455 mL |
References
- [1] Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46.
- [2] Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158.
- [3] Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.
Synonyms