[CAS NO. 442665-87-4] OGT-IN-2

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PRODUCTS SPECIFICATIONS [442665-87-4]

Catalog

HY-136282

Brand

MCE

CAS

442665-87-4

DESCRIPTION [442665-87-4]

Overview

MDL	-
Molecular Weight	446.99
Molecular Formula	C23H27ClN2O3S
SMILES	O=C(C1)N(/C(SC1C(O)=O)=N/C(C=C2)=CC=C2Cl)CCC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3

For research use only. We do not sell to patients.

Summary

OGT-IN-2 (compound 4) is a potent O-GlcNAc transferase (OGT) inhibitor, with IC ₅₀ values of 30 and 53 μM for sOGT and ncOGT, respectively ^[1] .

IC50 & Target

IC50: 30 ± 2 μM (sOGT), 53 ± 7 μM (ncOGT) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 279.65 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2372 mL	11.1859 mL	22.3719 mL
5 mM	0.4474 mL	2.2372 mL	4.4744 mL
10 mM	0.2237 mL	1.1186 mL	2.2372 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (4.65 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Gross BJ, et al. Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc. 2005 Oct 26;127(42):14588-9.