[CAS NO. 4443-09-8] Norwogonin
PRODUCTS SPECIFICATIONS [4443-09-8]
DESCRIPTION [4443-09-8]
Overview
| MDL | MFCD00016946 |
|---|---|
| Molecular Weight | 270.24 |
| Molecular Formula | C15H10O5 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC(O)=C13 |
Summary
Norwogonin, isolated from Scutellaria baicalensis Georgi , possesses antiviral activity against Enterovirus 71 (EV71) with an IC 50 of 31.83 μg/ml [1]
IC50 & Target
IC50: 31.83 μg/ml (EV71) [1]
In Vitro
Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection
[1]
.
Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression
[1]
.
Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL ( 925.10 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7004 mL | 18.5021 mL | 37.0041 mL |
| 5 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL |
| 10 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL |
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1.
Synonyms