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[CAS NO. 4481-62-3] Betulonic acid
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N1451 |
| Brand: | MCE |
| CAS: | 4481-62-3 |
Overview
| MDL | MFCD08459607 |
|---|---|
| Molecular Weight | 454.68 |
| Molecular Formula | C30H46O3 |
| SMILES | CC1(C)C(CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
Plasmodium
|
HSV-1
|
In Vitro
Betulonic acid (72 h) inhibits the growth of various types of human tumor cell lines, including MGC-803, PC3, Bcap-37, A375, MCF-7 tumor cell lines, with IC
50
s of 17.7, 13.9, 25.7, 28.9, 18.2 μM, respectively
[2]
.
Betulonic acid has antiplasmodial activity, with IC
50
of 10 μM
[3]
.
Betulonic acid inhibits HSV-1, ECHO6 and influenza FPV viruses, with EC
50
s of 0.9, 73.32, and 5.7 µM, respectively
[4]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 6.67 mg/mL ( 14.67 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1993 mL | 10.9967 mL | 21.9935 mL |
| 5 mM | 0.4399 mL | 2.1993 mL | 4.3987 mL |
| 10 mM | 0.2199 mL | 1.0997 mL | 2.1993 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 0.67 mg/mL (1.47 mM); Clear solution
References
- [1] Bastos DZL, et, al. Biotransformation of betulinic and betulonic acids by fungi. Phytochemistry. 2007 Mar;68(6):834-9.
- [2] Yang SJ, et, al. Synthesis and biological evaluation of betulonic acid derivatives as antitumor agents. Eur J Med Chem. 2015;96:58-65.
- [3] Sá MS, et, al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Res. 2009 Jul;105(1):275-9.
- [4] Pavlova NI, et, al. Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia. 2003 Jul;74(5):489-92.
Synonyms
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