[CAS NO. 451496-96-1] ML148
PRODUCTS SPECIFICATIONS [451496-96-1]
DESCRIPTION [451496-96-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 319.40 |
| Molecular Formula | C20H21N3O |
| SMILES | O=C(N1CCCCC1)C2=CC=C3N(C=NC3=C2)C4=CC=CC(C)=C4 |
Summary
IC50 & Target
IC 50 : 56 nM (15-PGDH) [1]
In Vitro
ML148 (compound 13) shows selectivity with IC
50
s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively
[1]
.
ML148 (10, 20 nM) decrease V
max
by 25% and reduces the apparent K
m
by half at a concentration of 10 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 156.54 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1309 mL | 15.6544 mL | 31.3087 mL |
| 5 mM | 0.6262 mL | 3.1309 mL | 6.2617 mL |
| 10 mM | 0.3131 mL | 1.5654 mL | 3.1309 mL |