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[CAS NO. 473268-46-1] ADDA 5 hydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-U00448 |
| Brand: | MCE |
| CAS: | 473268-46-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 406.00 |
| Molecular Formula | C24H36ClNO2 |
| SMILES | OC(COCCC1(C2)CC3CC2CC(C3)C1)CN4CC5=C(C=CC=C5)CC4.[H]Cl |
2 Publications Citing Use of MCE
Summary
ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO) , with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.
IC50 & Target
IC50: 18.93 μM (CcO, human glioma), 31.82 μM (CcO, bovine heart) [1]
In Vitro
ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC 50 s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC 50 of 8.17 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 65 mg/mL ( 160.10 mM ; Need ultrasonic)
H 2 O : 2 mg/mL ( 4.93 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4631 mL | 12.3153 mL | 24.6305 mL |
| 5 mM | 0.4926 mL | 2.4631 mL | 4.9261 mL |
| 10 mM | 0.2463 mL | 1.2315 mL | 2.4631 mL |
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