[CAS NO. 480-11-5]  Oroxylin A

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PRODUCTS SPECIFICATIONS [480-11-5]

Catalog
HY-N0560
Brand
MCE
CAS
480-11-5

DESCRIPTION [480-11-5]

Overview

MDLMFCD02259441
Molecular Weight284.26
Molecular FormulaC16H12O5
SMILESO=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13

For research use only. We do not sell to patients.


Summary

Oroxylin A is a natural active flavonoid with strong anticancer effects. IC50 value: Target: In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 32 mg/mL ( 112.57 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
* Please refer to the solubility information to select the appropriate solvent.


Synonyms

4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-
Flavone, 5,7-dihydroxy-6-methoxy-
Oroxylin
5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
Oroxylin A
6-Methoxybaicalein
5,7-Dihydroxy-6-methoxyflavone
Baicalein 6-methyl ether