[CAS NO. 480-20-6] Dihydrokaempferol

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PRODUCTS SPECIFICATIONS [480-20-6]

Catalog

HY-N2897

Brand

MCE

CAS

480-20-6

DESCRIPTION [480-20-6]

Overview

MDL	MFCD00189454
Molecular Weight	288.25
Molecular Formula	C15H12O6
SMILES	O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC=C(O)C=C3)[C@H]1O

For research use only. We do not sell to patients.

Summary

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs ^[1] .

IC50 & Target

Apoptosis; Bcl-2; Bcl-xL ^[1]

In Vitro

Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs ^[1] .
Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively) ^[1] .
Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[1]

Cell Line:	Normal synoviocyte cells; RA-FLS cells
Concentration:	0.3 μM, 3 μM, 30 μM, 300 μM
Incubation Time:	48 hours
Result:	Decreased the proliferation of RA-FLSs.

Apoptosis Analysis ^[1]

Cell Line:	RA-FLS cells
Concentration:	3 μM, 30 μM
Incubation Time:	48 hours
Result:	Induced apoptosis in RA-FLSs.

Western Blot Analysis ^[1]

Cell Line:	RA-FLS cells
Concentration:	3 μM, 30 μM
Incubation Time:	48 hours
Result:	Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 867.30 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4692 mL	17.3461 mL	34.6921 mL
5 mM	0.6938 mL	3.4692 mL	6.9384 mL
10 mM	0.3469 mL	1.7346 mL	3.4692 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160.

Synonyms

4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)-

Flavanone, 3,4′,5,7-tetrahydroxy-

4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R-trans)-

(2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Aromadendrin

Aromadendrol

Dihydrokaempferol

Katuranin

Aromadendrine

(+)-Dihydrokaempferol

3,4′,5,7-Tetrahydroxyflavanone

(+)-Aromadendrin

(2R,3R)-Katuranin

(2R,3R)-3,4′,5,7-Tetrahydroxyflavanone

(+)-(2R,3R)-Dihydrokaempferol