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[CAS NO. 480-66-0] Phloracetophenone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W008226 |
| Brand: | MCE |
| CAS: | 480-66-0 |
Overview
| MDL | MFCD00002287 |
|---|---|
| Molecular Weight | 168.15 |
| Molecular Formula | C8H8O4 |
| SMILES | CC(=O)C1=C(O)C=C(O)C=C1O |
Summary
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase ( CYP7A1 ) activity [1] . Phloracetophenone stimulats bile secretion mediated through Mrp2 [2] .
In Vitro
Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level
[1]
.
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 148.68 mM ; Need ultrasonic)
H 2 O : 2 mg/mL ( 11.89 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.9471 mL | 29.7354 mL | 59.4707 mL |
| 5 mM | 1.1894 mL | 5.9471 mL | 11.8941 mL |
| 10 mM | 0.5947 mL | 2.9735 mL | 5.9471 mL |
References
- [1] Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515(1-3):43-6.
- [2] Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387(2):221-7.
Synonyms
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