[CAS NO. 482646-13-9] A2ti-2
PRODUCTS SPECIFICATIONS [482646-13-9]
DESCRIPTION [482646-13-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 354.43 |
| Molecular Formula | C18H18N4O2S |
| SMILES | O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3 |
Summary
IC50 & Target
IC50: 230 μM (A2t) [1]
In Vitro
A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker
[1]
.
A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 705.36 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8214 mL | 14.1072 mL | 28.2143 mL |
| 5 mM | 0.5643 mL | 2.8214 mL | 5.6429 mL |
| 10 mM | 0.2821 mL | 1.4107 mL | 2.8214 mL |
References
- [1] Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.
- [2] Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90.