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[CAS NO. 485-72-3] Formononetin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0183 |
| Brand: | MCE |
| CAS: | 485-72-3 |
Overview
| MDL | MFCD00016948 |
|---|---|
| Molecular Weight | 268.26 |
| Molecular Formula | C16H12O4 |
| SMILES | O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O)=CC=C13 |
7 Publications Citing Use of MCE
- [1]Acta Pharm Sin B. 2021 Jan;11(1):143-155.
- [2]Genomics. 2021 Jun 7;S0888-7543(21)00220-2.
- [3]Mol Med. 2019 Dec;20(6):4984-4992.
- [4]Biochem Biophys Res Commun. 2020 May 7;525(3):759-766.
- [5]Biosci Rep. 2020 Oct 30;40(10):BSR20201349.
- [6]Mol Med Rep. 2020 Mar;21(3):1192-1200.
- [7]Biomed Chromatogr. 2019 Sep;33(9):e4563.
Summary
IC50 & Target
|
FGFR2 4.31 μM (IC 50 ) |
In Vitro
Formononetin is one of the major isoflavonoid constituents isolated from Astragalus membranaceus and has been demonstrated diverse pharmacological benefits. Formononetin possesses anti-angiogenic activity in human colon cancer cells. Formononetin also promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells
[1]
.
Formononetin (25 to 150 μM) markedly decreases the proliferation of endothelial cells stimulated by FGF2
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | HUVECs |
| Concentration: | 0, 10, 25, 50, 75, 100, and 150 μM |
| Incubation Time: | |
| Result: | Significantly decreased the proliferation of HUVECs stimulated by FGF2 in a dose-dependent manner, while had little inhibitory effects on HUVECs that were not stimulated by FGF2. |
In Vivo
Formononetin dramatically suppresses tumor volumes and the Formononetin-treated group tumor weight are significantly inhibited compared with the vehicle group . Formononetin treatment is well tolerated, and there is no significant difference in weight between vehicle group and formononetin treated groups [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | BALB/c nude mice bearing MDA-MB-231 xenografts [1] |
| Dosage: | 100 mg/kg |
| Administration: | Treated daily by intragastric administration for 25 days |
| Result: | Inhibited breast cancer growth and angiogenesis in vivo. |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 35 mg/mL ( 130.47 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7277 mL | 18.6386 mL | 37.2773 mL |
| 5 mM | 0.7455 mL | 3.7277 mL | 7.4555 mL |
| 10 mM | 0.3728 mL | 1.8639 mL | 3.7277 mL |
Synonyms
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