[CAS NO. 486443-73-6]  LC3-mHTT-IN-AN1

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PRODUCTS SPECIFICATIONS [486443-73-6]

Catalog
HY-130258
Brand
MCE
CAS
486443-73-6

DESCRIPTION [486443-73-6]

Overview

MDL-
Molecular Weight411.04
Molecular FormulaC15H9Br2NO3
SMILESBrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

For research use only. We do not sell to patients.

Summary

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons [1] .


IC50 & Target

mHTT-LC3 Linker Compound


In Vitro

LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 304.11 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4329 mL 12.1643 mL 24.3285 mL
5 mM 0.4866 mL 2.4329 mL 4.8657 mL
10 mM 0.2433 mL 1.2164 mL 2.4329 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution

* All of the co-solvents are available by MCE.