MDL | - |
---|---|
Molecular Weight | 411.04 |
Molecular Formula | C15H9Br2NO3 |
SMILES | BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O |
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons [1] .
mHTT-LC3 Linker Compound
LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 125 mg/mL ( 304.11 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.4329 mL | 12.1643 mL | 24.3285 mL |
5 mM | 0.4866 mL | 2.4329 mL | 4.8657 mL |
10 mM | 0.2433 mL | 1.2164 mL | 2.4329 mL |