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[CAS NO. 50-23-7] Hydrocortisone

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Catalog:	HY-N0583
Brand:	MCE
CAS:	50-23-7

Overview

MDL	-
Molecular Weight	362.46
Molecular Formula	C21H30O5
SMILES	C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1

For research use only. We do not sell to patients.

22 Publications Citing Use of MCE

[1]Nature. 2021 Jan;589(7843):620-626.
[2]Nat Chem Biol. 2022 Aug 18.
[3]JCI Insight. 2021 Jun 22;6(12):142838.
[4]Cancers (Basel). 2022 Aug 18;14(16):3986.
[5]Cancer Commun (Lond). 2021 Jul;41(7):576-595.
[6]Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.
[7]Mol Cell Endocrinol. 2022 Feb 11;547:111597.
[8]Chem Biol Interact. 2022 Jan 5;109798.
[9]J Ethnopharmacol. 2022 May 10;289:115018.
[10]Front Endocrinol. 2022 Feb 24;13:816229.
[11]Exp Cell Res. 2020 Aug 1;393(1):112054.
[12]Eur J Pharmacol. 2023 Feb 15;941:175499.
[13]Cancer Manag Res. 2019 Jun 21;11:5557-5572.
[14]Oncol Lett. 2021 Apr 27.
[15]Immunopharmacol Immunotoxicol. 2022 May 30;1-14.
[16]Tissue Cell. 2 September 2022, 101915.
[17]Food Sci Nutr. 2022 Jan 18;10(2):564-576.
[18]Exp Ther Med. 2021 Jun 3.
[19]Research Square Print. December 5th, 2022.
[20]Adv Biol (Weinh). 2022 Nov 14;e2200130.
[21]Research Square Preprint. 2022 Jul.
[22]Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.

Summary

Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex ^[1] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer ^[1] . Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5 ^[2] . Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03349281	Julio Barredo, MD\|Takeda\|University of Miami	Refractory Acute Lymphoblastic Leukemia\|Relapsed Acute Lymphoblastic Leukemia	March 25, 2019	Phase 1
NCT00396344	Dartmouth-Hitchcock Medical Center\|National Institute of Allergy and Infectious Diseases (NIAID)	Sepsis	October 2006	Not Applicable
NCT00862381	University Hospital, Grenoble	Patient Admitted in Reanimation	October 2008	Phase 3
NCT03153917	Hospices Civils de Lyon	Shift-Work Sleep Disorder	June 2, 2017	Not Applicable
NCT02408068	Diurnal Limited\|Simbec Research	Healthy	January 2015	Phase 1
NCT01860664	Koffler Vision Group\|Fera Pharmaceuticals, LLC	Allergic Conjunctivitis	May 2013	Phase 2
NCT00676585	Beth Israel Deaconess Medical Center\|American Heart Association	Cardiac Arrest	October 2007	Phase 1\|Phase 2
NCT03449797	University Hospital Padova	Primary Aldosteronism Due to Aldosterone Producing Adenoma	April 1, 2018	Not Applicable
NCT02722200	Yale University\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Obesity	May 2016	Phase 1
NCT05476770	Therapeutic Advances in Childhood Leukemia Consortium	Hematologic Malignancy\|AML\|ALL\|BPDCN\|MDS\|Lymphoblastic Lymphoma\|Lymphoma, B-Cell\|Lymphoma, T-Cell\|Hodgkin Lymphoma\|Mixed Phenotype Acute Leukemia\|Acute Undifferentiated Leukemia	November 11, 2022	Phase 1
NCT01595386	University of Alabama at Birmingham	Heart Disease Congenital Complex	April 2012	Not Applicable
NCT02756546	Cairo University	Systemic Lupus Erythematosis	September 2014	Phase 1\|Phase 2
NCT03896659	University of Texas Southwestern Medical Center\|University of California, Irvine	Hydrocortisone\|Depression\|Healthy Volunteers	October 1, 2019	Phase 4
NCT01700946	St. Jude Children´s Research Hospital\|Cookies for Kids´ Cancer\|Assisi Foundation	Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood B-Lymphoblastic Lymphoma	April 15, 2013	Phase 2
NCT01859312	National Institutes of Health Clinical Center (CC)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Adrenal Insufficiency\|Excess Androgen\|Congenital Adrenal Hyperplasia (CAH)	May 6, 2013	Phase 2
NCT02714543	The Oxford Dental College, Hospital and Research Center, Bangalore, India	Oral SubMucous Fibrosis	November 2013	Phase 3
NCT00557193	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Lymphoblastic Leukemia\|Acute Undifferentiated Leukemia\|Childhood T Acute Lymphoblastic Leukemia	January 14, 2008	Phase 3
NCT01422733	University of Virginia	Hyperandrogenemia\|Obesity\|Polycystic Ovary Syndrome	June 1, 2018	Early Phase 1
NCT00131053	Japan Adult Leukemia Study Group	Lymphoblastic Leukemia, Acute	September 2002	Phase 2
NCT01782859	Hospital for Special Surgery, New York	Total Hip Replacement	October 2012	Not Applicable
NCT04567433	The George Institute for Global Health, Australia	Sepsis\|Septic Shock	September 14, 2020
NCT04180969	Wayne State University	Stress\|Healthy	January 2023	Phase 2
NCT05193396	Marianne Andersen\|Odense University Hospital	Adrenal Insufficiency	February 2022	Phase 4
NCT01156519	Nantes University Hospital	Obesity	June 2010	Not Applicable
NCT01014364	University of Versailles\|Assistance Publique - Hôpitaux de Paris	Pneumonia, Viral\|Influenza in Humans	March 2010	Phase 3
NCT00002816	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	December 1996	Phase 3
NCT00688987	Oregon Health and Science University	Obesity\|Addison´s Disease	August 2000	Not Applicable
NCT04591990	Assistance Publique - Hôpitaux de Paris	Postresuscitation Syndrome	May 27, 2021	Phase 3
NCT00334672	Children´s Cancer and Leukaemia Group\|National Cancer Institute (NCI)	Nonneoplastic Condition	March 2006	Phase 3
NCT00490828	Ludwig-Maximilians - University of Munich	Systemic Inflammatory Response Syndrome\|Posttraumatic Stress Disorder	June 2007	Phase 4
NCT00709839	Medical University of Vienna	Healthy	June 2008	Phase 4
NCT01047670	Unidade de Terapia Intensiva	Mechanical Ventilation\|Mortality	May 2008	Phase 2\|Phase 3
NCT03910088	Cairo University	Post-Dural Puncture Headache	April 20, 2019	Phase 4
NCT01525680	Bronx VA Medical Center\|United States Department of Defense	Post Traumatic Stress Disorder	April 2011	Not Applicable
NCT00801957	Astellas Pharma Inc	Atopic Dermatitis	March 2003	Phase 2
NCT00003215	Swiss Group for Clinical Cancer Research	Lymphoma	April 1997	Phase 3
NCT00368381	CAMC Health System	Sepsis\|Adrenal Insufficiency	September 2006	Phase 4
NCT02289989	Rutgers, The State University of New Jersey	Atopic Dermatitis	November 2014	Not Applicable
NCT03286634	National Hospital Organization Nagoya Medical Center	Down Syndrome\|Acute Lymphoblastic Leukemia\|Childhood Cancer	April 18, 2017	Phase 2
NCT00618501	Asan Medical Center\|National Cancer Institute (NCI)	Leukemia	October 2005	Phase 2
NCT00019409	National Institutes of Health Clinical Center (CC)\|National Cancer Institute (NCI)	Leukemia	October 1999	Phase 3
NCT02112019	Derk Jan Jager\|Amsterdam UMC, location VUmc	Sjögren´s Syndrome	June 2014	Not Applicable
NCT01546922	University Medical Center Groningen	Adrenal Insufficiency	February 2012	Phase 4
NCT05408481	Assiut University	COVID-19	June 2022
NCT03217760	University Hospital, Brest	Endodontic Treatment	March 28, 2017
NCT00720109	National Cancer Institute (NCI)	Acute Lymphoblastic Leukemia\|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1\|Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1	July 14, 2008	Phase 2\|Phase 3
NCT03012425	Memorial Sloan Kettering Cancer Center\|Hunter College of City University of New York	Insomnia\|Related Distress Among Cancer Caregivers	January 3, 2017	Not Applicable
NCT02889224	University Hospital, Bordeaux	Cushing´s Syndrome	February 2012	Not Applicable
NCT00002757	Children´s Oncology Group\|National Cancer Institute (NCI)\|Societe Francaise Oncologie Pediatrique\|Children´s Cancer and Leukaemia Group	Leukemia\|Lymphoma	June 2001	Phase 3
NCT02116608	University of Colorado, Denver	Granuloma\|Tracheostomy	September 2014	Phase 4
NCT00004669	National Center for Research Resources (NCRR)\|Penn State University\|Office of Rare Diseases (ORD)	Bronchopulmonary Dysplasia	June 1996	Phase 2
NCT04924166	Rachel Yehuda\|James J. Peters Veterans Affairs Medical Center\|The Chaim Sheba Medical Center\|Icahn School of Medicine at Mount Sinai	PTSD\|Acute Stress Disorder\|Trauma-related Stressor	September 23, 2021	Phase 2
NCT04597762	Hospital Hietzing	Dry Eye Syndromes	August 31, 2020	Not Applicable
NCT05160506	Beth Israel Deaconess Medical Center	Pancreatitis\|Pancreatitis, Acute\|Corticosteroid\|Hydrocortisone	April 2022	Phase 2
NCT02837432	Stanford University	Depression	July 2016	Early Phase 1
NCT01450930	Bruno Allolio\|University of Wuerzburg	Primary Adrenal Insufficiency	November 2011	Phase 2
NCT02266589	Nanjing PLA General Hospital	Septic Shock\|Sepsis	November 2011	Phase 3
NCT05446779	Helsinki University Central Hospital\|Finnish Institute for Health and Welfare\|University of Helsinki\|Tampere University Hospital\|Tampere University	Primary Aldosteronism\|Adrenal Cushing Syndrome\|Pheochromocytoma\|Endocrine Neoplasia	June 3, 2022
NCT02517489	University Hospital, Tours	Community Acquired Pneumonia	October 28, 2015	Phase 3
NCT05435781	Ulla Feldt-Rasmussen\|Aarhus University Hospital\|Odense University Hospital\|Rigshospitalet, Denmark	Adrenal Insufficiency\|Polymyalgia Rheumatica\|Giant Cell Arteritis	June 7, 2022	Phase 4
NCT02043587	University of California, San Diego\|Leadiant Biosciences, Inc.	Acute Lymphocytic Leukemia\|Adult Lymphoblastic Lymphoma	January 2014	Phase 2
NCT04197115	IMSS Hospital General de Zona 11, Piedras Negras	Sepsis\|Septic Shock	September 1, 2019	Phase 3
NCT00507832	University Hospital Muenster\|Novartis Pharmaceuticals	Prurigo Nodularis	April 2007	Phase 2
NCT00529841	Baylor College of Medicine	Adrenal Hyperplasia, Congenital	January 2007	Not Applicable
NCT01540812	PETHEMA Foundation	Acute Lymphoblastic Leukemia	February 2012
NCT01874860	University of Louisville\|James Graham Brown Cancer Center	Colorectal Cancer\|Head and Neck Cancer	August 2013	Phase 2
NCT01104025	Children´s Hospital Medical Center, Cincinnati	Hemophagocytic Lymphohistiocytosis	April 2010	Phase 2
NCT00590018	Baylor College of Medicine	Cardiac Output, Low	February 2003	Phase 2
NCT00673270	Rennes University Hospital	Renin Angiotensin	May 2008	Phase 1\|Phase 2
NCT05320380	LLS PedAL Initiative, LLC\|Children´s Oncology Group\|ImmunoGen, Inc.\|National Cancer Institute (NCI)	Recurrent Acute Myeloid Leukemia\|Recurrent B Acute Lymphoblastic Leukemia\|Recurrent Mixed Phenotype Acute Leukemia\|Recurrent T Acute Lymphoblastic Leukemia\|Refractory Acute Myeloid Leukemia\|Refractory B Acute Lymphoblastic Leukemia\|Refractory Mixed Phenotype Acute Leukemia\|Refractory T Acute Lymphoblastic Leukemia	December 20, 2022	Phase 1\|Phase 2
NCT02425852	Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives	Ulcerative Colitis	December 2016	Phase 4
NCT00002744	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	May 1996	Phase 3
NCT03623555	Ximena Goldberg\|Fundación Bancaria La Caixa\|Universitat Autonoma de Barcelona\|Associació Catalana d´Universitats Públiques\|Corporacion Parc Tauli	Violence, Domestic\|Stress Related Disorder\|Depressive Disorder	March 1, 2019
NCT03509350	Emory University\|The Marcus Foundation	Sepsis	August 22, 2018	Phase 3
NCT02114710	Nanjing PLA General Hospital	Coagulation Dysfunction in Septic Shock\|Hemodynamic Improvement Induced by Hydrocortisone	May 2009	Phase 3
NCT03758365	MC2 Therapeutics	Vasoconstriction	November 5, 2018	Phase 1
NCT00657306	University of Turin, Italy	Cirrhosis With Ascites	May 2008	Phase 2
NCT00236925	Ludwig-Maximilians - University of Munich\|University of Zurich	Fibromyalgia	May 2003	Early Phase 1
NCT04456439	Mesoblast International Sàrl\|Mesoblast, Ltd.	Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
NCT03773822	CMC Ambroise Paré	Cardiogenic Shock	April 19, 2019	Phase 3
NCT00172354	National Taiwan University Hospital	Heart Arrest	October 2004	Not Applicable
NCT05159284	Laboratorios Thea, Spain	Dry Eye\|Meibomian Gland Dysfunction	November 9, 2021	Phase 4
NCT02883049	National Cancer Institute (NCI)	B Acute Lymphoblastic Leukemia\|Central Nervous System Leukemia\|Ph-Like Acute Lymphoblastic Leukemia\|Testicular Leukemia	February 27, 2012	Phase 3
NCT03830060	Assiut University	Acute Pancreatitis	February 25, 2019
NCT04348305	Scandinavian Critical Care Trials Group\|Rigshospitalet, Denmark\|Copenhagen Trial Unit, Center for Clinical Intervention Research\|University of Copenhagen\|Aarhus University Hospital	Covid-19\|Hypoxia	April 17, 2020	Phase 3
NCT00732277	University Hospital Southampton NHS Foundation Trust\|Imperial College London\|St Mary´s NHS Trust\|University of Bristol\|University Hospitals Bristol and Weston NHS Foundation Trust	Sepsis	April 2008	Phase 2
NCT01574014	University Hospital Inselspital, Berne\|University of Basel	Phobic Disorders\|Phobias	July 2009	Phase 2
NCT02270827	Royal Brompton & Harefield NHS Foundation Trust	Asthma	June 2014
NCT02152553	Vastra Gotaland Region	Addison Disease	May 2014	Not Applicable
NCT01186328	Therapeutic Advances in Childhood Leukemia Consortium\|Enzon Pharmaceuticals, Inc.	Lymphoblastic Leukemia, Acute\|Lymphoblastic Leukemia, Acute, Childhood\|Leukemia, Lymphoblastic, Acute, T Cell\|Leukemia, Lymphoblastic, Acute	August 24, 2010	Phase 1
NCT02419755	St. Jude Children´s Research Hospital	Mixed Lineage Acute Leukemia\|Acute Myeloid Leukemia\|Acute Lymphoid Leukemia	April 14, 2015	Phase 2
NCT02001207	Seoul National University Hospital	Critically Ill	July 2013
NCT02700828	Semmelweis University	Hypoxic-Ischemic Encephalopathy\|Asphyxia	February 2016	Phase 2\|Phase 3
NCT01095172	Guy´s and St Thomas´ NHS Foundation Trust\|Astellas Pharma Europe Ltd.	Function of Renal Transplant	November 2010	Phase 4
NCT01960530	Diurnal Limited\|Simbec Research	Adrenal Insufficiency	October 2013	Phase 1
NCT03032250	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Caregiver\|Malignant Head and Neck Neoplasm\|Paranasal Sinus Squamous Cell Carcinoma\|Salivary Gland Squamous Cell Carcinoma\|Stage I Hypopharyngeal Squamous Cell Carcinoma\|Stage I Laryngeal Squamous Cell Carcinoma\|Stage I Lip and Oral Cavity Squamous Cell Carcinoma\|Stage I Oropharyngeal Squamous Cell Carcinoma\|Stage II Hypopharyngeal Squamous Cell Carcinoma\|Stage II Laryngeal Squamous Cell Carcinoma\|Stage II Lip and Oral Cavity Squamous Cell Carcinoma\|Stage II Oropharyngeal Squamous Cell Carcinoma\|Stage III Hypopharyngeal Squamous Cell Carcinoma\|Stage III Laryngeal Squamous Cell Carcinoma\|Stage III Lip and Oral Cavity Squamous Cell Carcinoma\|Stage III Oropharyngeal Squamous Cell Carcinoma\|Stage IV Hypopharyngeal Squamous Cell Carcinoma\|Stage IV Laryngeal Squamous Cell Carcinoma\|Stage IV Lip and Oral Cavity Squamous Cell Carcinoma\|Stage IV Oropharyngeal Squamous Cell Carcinoma\|Stage IVA Hypopharyngeal Squamous Cell Carcinoma\|Stage IVA Laryngeal Squamous Cell Carcinoma\|Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma\|Stage IVA Oropharyngeal Squamous Cell Carcinoma\|Stage IVB Hypopharyngeal Squamous Cell Carcinoma\|Stage IVB Laryngeal Squamous Cell Carcinoma\|Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma\|Stage IVB Oropharyngeal Squamous Cell Carcinoma\|Stage IVC Hypopharyngeal Squamous Cell Carcinoma\|Stage IVC Laryngeal Squamous Cell Carcinoma\|Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma\|Stage IVC Oropharyngeal Squamous Cell Carcinoma\|Recurrent Head and Neck Squamous Cell Carcinoma\|Recurrent Hypopharyngeal Squamous Cell Carcinoma\|Recurrent Laryngeal Squamous Cell Carcinoma\|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma\|Recurrent Oropharyngeal SCC\|Recurrent Paranasal Sinus Squamous Cell Carcinoma	May 15, 2017	Not Applicable
NCT03929627	Medical University of Vienna\|Austrian Federal Ministry of Defence	Stress	April 30, 2017
NCT03718234	University of Minnesota	Congenital Adrenal Hyperplasia\|Hyperplasia\|Adrenal Hyperplasia\|Congenital Disorders\|Adrenocortical Hyperfunction\|Disorders of Sex Development\|Urogenital Abnormalities\|Genetic Diseases, Inborn\|Steroid Metabolic Diseases, Inborn\|Adrenal Gland Disease\|Hydrocortisone	January 1, 2019	Phase 1
NCT04821583	Erasmus Medical Center	Symmetric Lipomatoses, Multiple	June 1, 2021	Phase 3
NCT03110198	Xijing Hospital of Digestive Diseases\|Shanghai Tongji Hospital, Tongji University School of Medicine\|First Affiliated Hospital of Zhongshan Medical University	Ulcerative Colitis, Unspecified	May 2017	Phase 4
NCT01422707	University of Virginia	Hyperandrogenemia\|Obesity\|Polycystic Ovary Syndrome	January 19, 2018	Early Phase 1
NCT00623766	Bristol-Myers Squibb\|Medarex	Melanoma	July 2008	Phase 2
NCT01156480	NorthShore University HealthSystem\|University of Chicago	Necrotizing Enterocolitis	September 2009	Not Applicable
NCT05324618	Ain Shams University\|National Hepatology & Tropical Medicine Research Institute	Atopic\|Dermatitis	April 15, 2022	Phase 4
NCT02760862	Ain Shams University	Headache	October 2014	Phase 4
NCT01036594	University of California, San Francisco	Prostate Cancer	December 11, 2009	Phase 2
NCT00185692	Stanford University	Blood Cancer\|Leukemia\|Graft Versus Host Disease\|Malignancy\|CLL\|NHL\|Hodgkin´s Disease\|MDS	August 2000	Phase 2
NCT01301677	X-pert Med GmbH	Erythema\|Pain	January 2011	Phase 1
NCT02689856	Citius Pharmaceuticals, Inc.	Hemorrhoids	May 2015	Phase 2
NCT01761344	Haukeland University Hospital	Primary Hyperaldosteronism	January 2013	Not Applicable
NCT04599959	Boehringer Ingelheim	Covid-19	October 26, 2020	Not Applicable
NCT03358082	Sohag University	Vitiligo\|Tacrolimus	October 1, 2017	Phase 1\|Phase 2
NCT05246085	University of Colorado, Denver	Eosinophilic Esophagitis	August 10, 2022
NCT05607901	Tanta University	Dermatologic Disease	October 28, 2022	Phase 2
NCT04301479	Instituto do Coracao	Vasoplegia\|Cardiac Surgery	March 2020	Phase 3
NCT00049569	National Cancer Institute (NCI)	L1 Childhood Acute Lymphoblastic Leukemia\|L2 Childhood Acute Lymphoblastic Leukemia\|Non-T, Non-B Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood Acute Lymphoblastic Leukemia\|T-cell Childhood Acute Lymphoblastic Leukemia	January 2003	Not Applicable
NCT00980876	Farmoquimica S.A.\|Pharmagenix Projetos em Medicina Farmacêutica Ltda.	Otitis Externa	April 2012	Phase 3
NCT00855270	Sheba Medical Center\|National Institute of Mental Health (NIMH)\|Icahn School of Medicine at Mount Sinai	Post Traumatic Stress Disorder	April 2009	Not Applicable
NCT00442390	University of Aarhus	Addison Syndrome	January 2002	Not Applicable
NCT01710202	University of Texas at Austin	Major Depressive Disorder\|Anxiety Disorders	October 2012
NCT01608945	Eastern Hepatobiliary Surgery Hospital	Some Studies Shows That the Steroid Can Reduce the Injury of the I+R of the Liver	April 2008
NCT01815918	Hospital for Special Surgery, New York	Total Knee Arthroplasty	February 2011	Phase 4
NCT04082533	Hospital for Special Surgery, New York	Pain\|Arthrofibrosis\|Osteoarthritis, Knee	July 24, 2019	Phase 4
NCT01063569	Haukeland University Hospital	Addison´s Disease	February 2010	Phase 2\|Phase 3
NCT02349217	M.D. Anderson Cancer Center	Breast Cancer	January 23, 2015	Not Applicable
NCT01460615	Tampere University Hospital	Postoperative Complications\|Postoperative Pancreatitis	February 2011	Phase 2
NCT05276323	Soroka University Medical Center	Atopic Dermatitis	October 1, 2020	Phase 2
NCT02790788	University of Athens\|University of Thessaly	Inhospital Cardiac Arrest	November 4, 2016	Phase 1\|Phase 2
NCT00773058	Southeast University, China\|Nanjing Medical University	Acute Respiratory Distress Syndrome\|Adrenal Insufficiency	December 2008	Phase 4
NCT01093261	Nantes University Hospital\|Société Française d´Anesthésie et de Réanimation	Traumatic Brain Injury\|Trauma\|Adrenal Insufficiency\|Pneumonia	August 2010	Phase 3
NCT00181597	Genzyme, a Sanofi Company\|Sanofi	Prostate Cancer\|Prostate Adenocarcinoma	March 2004	Phase 2
NCT04508946	Air Force Specialized Hospital, Cairo, Egypt	Septic Shock\|Sepsis\|Organ Dysfunction Syndrome Sepsis	August 1, 2019	Phase 3
NCT03422159	Community Medical Center, Toms River, NJ	Sepsis, Severe\|Septic Shock	February 5, 2018	Phase 2
NCT02090309	Soroka University Medical Center	Injuries, Whiplash	March 2014	Phase 2
NCT03602378	University of Split, School of Medicine\|General Hospital Zadar	Developmental Disability\|Chronic Disease\|Down Syndrome\|Autism Spectrum Disorder\|Pervasive Developmental Disorder\|Cerebral Palsy\|Diabetes Mellitus, Type 1\|Epilepsy\|Asthma\|Stress	April 2, 2018
NCT00006455	Gustave Roussy, Cancer Campus, Grand Paris	Lymphoma	November 26, 1999	Phase 3
NCT04181515	Wayne State University	Stress\|Opioid-use Disorder	January 2023	Phase 2
NCT04621565	Peking Union Medical College Hospital	Pituitary Adenoma\|Adrenal Insufficiency\|Surgery	November 1, 2020	Not Applicable
NCT02465307	University of Florida\|U.S. National Science Foundation\|National Institute for Biomedical Imaging and Bioengineering (NIBIB)\|National Institute of Neurological Disorders and Stroke (NINDS)	Delirium\|Confusion	February 2016
NCT02256865	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Insulin Resistance	October 2014	Early Phase 1
NCT00400946	Dana-Farber Cancer Institute\|National Cancer Institute (NCI)	Drug+Agent Toxicity by Tissue+Organ\|Leukemia	April 2005	Phase 3
NCT00149123	Hospices Civils de Lyon	Burns	April 2005	Phase 4
NCT00953576	Dana-Farber Cancer Institute\|Beth Israel Deaconess Medical Center\|Brigham and Women´s Hospital\|Massachusetts General Hospital\|Prostate Cancer Foundation Clinical Research Consortium\|GlaxoSmithKline	Prostate Cancer	September 29, 2009	Phase 1\|Phase 2
NCT00729794	University of Athens\|University of Thessaly	Cardiac Arrest	September 2008	Phase 3
NCT03335124	University Medical Centre Ljubljana	Sepsis\|Septic Shock\|Critical Illness\|Fluid Overload	September 26, 2017	Phase 4
NCT04921189	Asan Medical Center\|Seoul St. Mary´s Hospital\|Wonju Severance Christian Hospital\|Samsung Changwon Hospital\|Samsung Medical Center\|Chung-Ang University\|Hanyang University\|Ewha Womans University\|Hanil General Hospital	Out-Of-Hospital Cardiac Arrest\|Postcardiac Arrest Syndrome	June 4, 2021	Phase 2
NCT05350020	The London Clinic	Addison´s Disease	March 14, 2022	Phase 4
NCT03020030	Dana-Farber Cancer Institute\|Servier	Acute Lymphoblastic Leukemia, Pediatric	March 3, 2017	Phase 3
NCT00476190	Dana-Farber Cancer Institute\|Massachusetts General Hospital\|Boston Children´s Hospital\|NCIC Clinical Trials Group	Acute Lymphoblastic Leukemia	April 2007	Phase 2
NCT00002704	National Cancer Institute (NCI)	Leukemia	January 1996	Phase 2
NCT00895310	University of California, Davis	Prostate Cancer	May 2009	Phase 2
NCT02768740	Association Niçoise de Réanimation Médicale	Septic Shock	April 2008	Phase 4
NCT03142893	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Sleep Restriction	May 8, 2017	Phase 1
NCT02552654	Charite University, Berlin, Germany	Intrusive Memories	September 2015	Not Applicable
NCT00167544	Nationwide Children´s Hospital\|National Institutes of Health (NIH)\|National Institute of Neurological Disorders and Stroke (NINDS)	Bronchopulmonary Dysplasia\|Encephalomalacia\|Premature Birth	November 2005	Phase 2
NCT00003593	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes\|Myelodysplastic+Myeloproliferative Neoplasms	June 1999	Phase 3
NCT01771328	Haukeland University Hospital	Adrenal Hyperplasia, Congenital	February 2013	Phase 2
NCT03792256	Children´s Oncology Group	Leukemia, Lymphocytic\|Lymphoblastic Lymphoma\|T-cell Lymphoma\|T-cell Leukemia\|Recurrent Disease\|Acute Leukemia	April 11, 2019	Phase 1
NCT01817153	Centre Hospitalier Régional d´Orléans	Septic Shock\|Adult	November 5, 2013	Phase 2\|Phase 3
NCT03649633	University of Athens	Septic Shock	September 6, 2018	Phase 1\|Phase 2
NCT03766997	Peking Union Medical College Hospital	Granulomatous Mastitis	February 19, 2019	Phase 4
NCT05457296	University Tunis El Manar	Adrenal Insufficiency	January 1, 2021	Phase 4
NCT03558971	Helen Foundation	Rheumatic Diseases	January 1, 2000	Phase 4
NCT00097474	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Institutes of Health Clinical Center (CC)	Jet Lag	December 21, 2004	Phase 2
NCT00536991	Roswell Park Cancer Institute\|National Cancer Institute (NCI)	Prostate Adenocarcinoma\|Recurrent Prostate Carcinoma\|Stage III Prostate Cancer\|Stage IV Prostate Cancer	October 2006	Phase 1\|Phase 2
NCT00526305	PETHEMA Foundation	Acute Lymphoblastic Leukemia	January 2000	Phase 4
NCT00542841	Maria I. New\|Office of Rare Diseases (ORD)\|National Center for Research Resources (NCRR)\|Icahn School of Medicine at Mount Sinai	21-hydroxylase Deficiency	August 2007	Not Applicable
NCT00859781	Weill Medical College of Cornell University\|United States Department of Defense	Prostate Cancer	June 2009	Phase 2
NCT02602210	Universitaire Ziekenhuizen KU Leuven	Liver Cirrhosis	January 2015	Phase 3
NCT02580240	Northern Jiangsu Province People´s Hospital	Septic Shock	September 2015	Not Applicable
NCT00098839	Children´s Oncology Group\|National Cancer Institute (NCI)	Recurrent Childhood Acute Lymphoblastic Leukemia	February 2005	Phase 1\|Phase 2
NCT01453686	The Hospital for Sick Children	Alopecia Areata	August 2002	Phase 3
NCT00027859	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|Southwest Oncology Group\|Cancer and Leukemia Group B	Prostate Cancer	May 2003	Phase 3
NCT04231708	Wayne State University	Opioid Use Disorder	January 2023	Phase 2
NCT02691858	Cairo University	Intussusception	April 2015	Not Applicable
NCT04435912	University of Jordan	Blood Pressure\|Heart Rate\|Airway Pressure	July 4, 2019	Early Phase 1
NCT02084134	Washington University School of Medicine	Pituitary Adenoma\|Pituitary Diseases	March 2012	Not Applicable
NCT02402114	Albert Einstein Healthcare Network	Post-Traumatic Stress Disorder	February 2, 2015	Not Applicable
NCT02266264	Srinakharinwirot University	Hyperglycemia	October 2014	Phase 4
NCT00675272	Kuopio University Hospital\|Tampere University Hospital	Brain Death	May 2008	Not Applicable
NCT00392834	AIDS Malignancy Consortium\|National Cancer Institute (NCI)\|The Emmes Company, LLC	Lymphoma	September 2006	Phase 2
NCT00705822	Sanofi	Prostatic Neoplasms	August 2006	Phase 3
NCT00354107	National Cancer Institute (NCI)	Anaplastic Large Cell Lymphoma\|Recurrent Childhood Anaplastic Large Cell Lymphoma	January 2007	Phase 1\|Phase 2
NCT04137302	Centre Hospitalier Régional d´Orléans\|French Anti-Doping Agency (AFLD)\|University Hospital, Tours	Anti-doping Campaign, Detection of Hydrocortisone	November 13, 2019	Phase 4
NCT02828358	National Cancer Institute (NCI)	Acute Leukemia of Ambiguous Lineage\|B Acute Lymphoblastic Leukemia\|Mixed Phenotype Acute Leukemia	March 27, 2017	Phase 2
NCT00704262	LEO Pharma	Psoriasis Vulgaris	May 2008	Phase 2
NCT03649009	Universiti Kebangsaan Malaysia Medical Centre	Hyperlactatemia	January 1, 2018	Not Applicable
NCT00186628	Stanford University\|The Leukemia and Lymphoma Society\|National Cancer Institute (NCI)	Leukemia, Mast-Cell\|Mantle-cell Lymphoma	June 2005	Phase 2
NCT00002855	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Prostate Cancer	August 1996	Phase 3
NCT00442494	Kuopio University Hospital\|Tampere University Hospital\|Oulu University Hospital	Atrial Fibrillation	October 2012	Not Applicable
NCT04615962	Seanergy Dermatology Ltd.	Atopic Dermatitis	January 1, 2021	Phase 1
NCT01718964	Prof. Dominique de Quervain, MD\|University of Basel	Opioid Dependence	November 2012	Phase 2
NCT00674570	VA Office of Research and Development	Stress Disorders, Posttraumatic	January 13, 2009	Phase 4
NCT00002760	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)	Prostate Cancer	August 1996	Phase 3
NCT01150409	The Cleveland Clinic	Septic Shock	May 2008	Phase 4
NCT00597857	Kent State University\|National Institute of Mental Health (NIMH)	Posttraumatic Stress Disorder	June 2005	Not Applicable
NCT04465539	Tanta University	Potential Therapeutic Role	July 15, 2020	Not Applicable
NCT00002881	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|Cancer and Leukemia Group B\|Southwest Oncology Group	Prostate Cancer	October 1996	Phase 3
NCT01055249	X-pert Med GmbH	Pain\|Inflammation\|Healthy Volunteers	January 2010	Phase 1
NCT02101853	National Cancer Institute (NCI)	Recurrent B Acute Lymphoblastic Leukemia	December 8, 2014	Phase 3
NCT04536662	Shanghai Jiao Tong University School of Medicine	Congenital Adrenal Hyperplasia	October 1, 2020	Phase 4
NCT02196142	University Hospital Inselspital, Berne	Alcohol Craving\|Psychological Stress\|Physiological Stress	November 2014	Phase 3
NCT00563303	Nantes University Hospital\|Serb	Polytraumatism	November 2006	Phase 2\|Phase 3
NCT00691002	LEO Pharma	Psoriasis Vulgaris	May 2008	Phase 3
NCT04293562	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Myeloid Leukemia	July 20, 2020	Phase 3
NCT02777268	Diurnal Limited\|Simbec Research	Healthy Subjects	July 2013	Phase 1
NCT02282150	Ulla Feldt-Rasmussen\|Rigshospitalet, Denmark	Adrenal Insufficiency	October 2016	Phase 4
NCT01769339	Janssen Pharmaceutica	Vulva; Candidiasis	January 2009	Phase 4
NCT01399268	Hospital for Special Surgery, New York	Postoperative Inflammatory Response	February 2009	Phase 4
NCT00625209	University of Versailles\|Assistance Publique - Hôpitaux de Paris\|Ministry of Health, France	Septic Shock	March 2008	Phase 3
NCT00853008	PETHEMA Foundation	Acute Lymphoblastic Leukemia	January 2003	Phase 4
NCT05139849	Tiohundra AB\|Sahlgrenska University Hospital, Sweden\|Stockholm South General Hospital	Cardiac Arrest;In-hospital Cardiac Arrest; Methylprednisolone; Vasopressin; Adrenaline; Randomized Clinical Trial	November 17, 2021	Phase 3
NCT03682393	Kuopio University Hospital	Atrial Fibrillation	January 1, 2020	Phase 2\|Phase 3
NCT02044159	Children´s Hospital of Eastern Ontario\|Alberta Children´s Hospital\|British Columbia Children´s Hospital\|London Health Sciences Centre\|St. Justine´s Hospital\|IWK Health Centre\|Montreal Children´s Hospital of the MUHC	Shock	July 2014	Phase 4
NCT03302416	University of Pittsburgh\|National Institute on Drug Abuse (NIDA)	Healthy	June 1, 2016	Early Phase 1
NCT00621985	Boston Children´s Hospital	Adrenal Hyperplasia, Congenital	April 2008	Phase 2
NCT03548246	University of Texas Southwestern Medical Center\|National Institutes of Health Clinical Center (CC)\|University of Michigan\|Children´s Hospital Los Angeles\|Feinstein Institute for Medical Research	Congenital Adrenal Hyperplasia	January 2023	Phase 2
NCT00358748	University of British Columbia\|BC Research Inc.	Neonatal Hypotension	July 2005	Phase 3
NCT01089075	Max-Planck-Institute of Psychiatry\|Novo Nordisk A+S	Partial Corticotrope Insufficiency	February 2010	Phase 4
NCT00001521	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Institutes of Health Clinical Center (CC)	Congenital Adrenal Hyperplasia (CAH)	June 8, 1995	Phase 2
NCT03261336	Donald Trump, MD\|Inova Health Care Services	Castration-resistant Prostate Cancer	January 6, 2017	Phase 2
NCT00873093	National Cancer Institute (NCI)	B-cell Adult Acute Lymphoblastic Leukemia\|B-cell Childhood Acute Lymphoblastic Leukemia\|Recurrent Adult Acute Lymphoblastic Leukemia\|Recurrent Adult Lymphoblastic Lymphoma\|Recurrent Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood Lymphoblastic Lymphoma\|T-cell Adult Acute Lymphoblastic Leukemia\|T-cell Childhood Acute Lymphoblastic Leukemia	March 2009	Phase 2
NCT00693693	Wake Forest University\|Wake Forest University Health Sciences	Atopic Dermatitis	November 2006	Phase 4
NCT01005758	Ohio State University Comprehensive Cancer Center\|National Cancer Institute (NCI)	Leukemia	January 2009	Phase 2
NCT02505815	University of Erlangen-Nürnberg Medical School	Neurocognitive Function	September 2014
NCT02671058	Cristcot LLC\|Parexel	Healthy	March 2016	Phase 1
NCT00550992	Dutch Childhood Oncology Group\|BFM Germany\|CORS Monza Italy\|Associazione Italiana Ematologia Oncologia Pediatrica\|Australian and New Zealand Children´s Oncology Group\|BFM Austria\|CLCG France Belgium Portugal\|COALL Germany\|CPH, Czech republic\|DFCI consortium USA\|FRALLE France\|Hong Kong\|MD Anderson USA\|NOPHO Scandinavian countries\|PINDA, Chile\|PPLLSG Poland\|Seattle USA\|SJCRH USA\|UKCCSG United Kingdom	Leukemia	January 2006	Not Applicable
NCT02481310	Northwestern University\|National Cancer Institute (NCI)\|Millennium Pharmaceuticals, Inc.	Adult Burkitt Lymphoma\|B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma\|Diffuse Large B-Cell Lymphoma\|MYC Gene Mutation\|Plasmablastic Lymphoma	October 28, 2015	Phase 1\|Phase 2
NCT01144065	Meir Medical Center	Acute Myocardial Infarction	August 2010
NCT00002471	Memorial Sloan Kettering Cancer Center	Leukemia\|Lymphoma	February 1990	Phase 2
NCT00623740	Assistance Publique - Hôpitaux de Paris	Bronchopulmonary Dysplasia	April 2008	Phase 3
NCT03062280	Diurnal Limited	Congenital Adrenal Hyperplasia	August 18, 2016	Phase 3
NCT01614197	Therapeutic Advances in Childhood Leukemia Consortium\|Pfizer	Lymphoblastic Leukemia, Acute, Childhood\|Lymphoblastic Lymphoma\|Peripheral T-cell Lymphoma	March 2015	Phase 1
NCT00706173	University of California, San Diego	Post-traumatic Stress Disorder	August 2009	Phase 4
NCT03389555	Beth Israel Deaconess Medical Center\|Open Philanthropy Project	Sepsis\|Septic Shock\|Metabolic Disturbance	February 9, 2018	Phase 2\|Phase 3
NCT03335774	Nivagen Pharmaceuticals Inc.	Internal Hemorrhoids	February 12, 2019	Phase 2
NCT04037605	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Sleep Restriction	February 9, 2020	Early Phase 1
NCT05008146	Rajesh Narendran\|National Institute on Drug Abuse (NIDA)\|University of Pittsburgh	Cocaine Use Disorder	June 4, 2019	Early Phase 1
NCT00670254	Charite University, Berlin, Germany\|German Federal Ministry of Education and Research\|SepNet - Critical Care Trials Group\|Coordination Centre for Clinical Trials Leipzig	Severe Sepsis	January 2009	Phase 3
NCT00751855	VISN 3 Mental Illness Research, Education and Clinical Center\|Bronx VA Medical Center	PTSD	July 2008	Not Applicable
NCT05354778	Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo\|Instituto do Cancer do Estado de São Paulo\|Hospital Samaritano Paulista\|Hospital de Câncer de Barretos\|Fundação Faculdade Regional de Medicina de São José do Rio Preto\|University of Sao Paulo	Healthcare-Associated Pneumonia\|Ventilator Associated Pneumonia	October 2022	Not Applicable
NCT00084838	Dana-Farber Cancer Institute\|National Cancer Institute (NCI)	Central Nervous System Tumor, Pediatric	February 2003	Phase 2
NCT00933023	Chelsea and Westminster NHS Foundation Trust	Phimosis	August 2009	Phase 4
NCT00006371	H. Lee Moffitt Cancer Center and Research Institute\|National Cancer Institute (NCI)\|Janssen Pharmaceuticals	Prostate Cancer	May 2000	Phase 2
NCT00451230	National Institute on Drug Abuse (NIDA)\|National Alliance for Research on Schizophrenia and Depression	Cocaine Dependence	June 2005	Not Applicable
NCT03592693	University of Athens\|General Hospital of Nikaia Saint Panteleimon\|Naval Hospital, Athens	Shock, Septic	September 6, 2018	Phase 2
NCT02112916	National Cancer Institute (NCI)	Adult T Acute Lymphoblastic Leukemia\|Ann Arbor Stage II Adult Lymphoblastic Lymphoma\|Ann Arbor Stage II Childhood Lymphoblastic Lymphoma\|Ann Arbor Stage III Adult Lymphoblastic Lymphoma\|Ann Arbor Stage III Childhood Lymphoblastic Lymphoma\|Ann Arbor Stage IV Adult Lymphoblastic Lymphoma\|Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma\|Childhood T Acute Lymphoblastic Leukemia	September 30, 2014	Phase 3
NCT00133991	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	July 2005	Phase 2
NCT00591006	University of Texas Southwestern Medical Center	Healthy	January 2008	Phase 3
NCT03019614	Diurnal Limited\|Simbec Research	Congenital Adrenal Hyperplasia\|Adrenal Insufficiency	March 2010	Phase 1
NCT03007147	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Lymphoblastic Leukemia\|B Acute Lymphoblastic Leukemia\|Mixed Phenotype Acute Leukemia\|T Acute Lymphoblastic Leukemia	July 28, 2017	Phase 3
NCT01448109	The George Institute\|National Health and Medical Research Council, Australia\|Australian and New Zealand Intensive Care Society Clinical Trials Group	Septic Shock	June 13, 2012	Phase 4
NCT01451515	St. Jude Children´s Research Hospital\|National University, Singapore	Lymphoblastic Lymphoma	May 25, 2012	Phase 2
NCT00874393	NICHD Neonatal Research Network\|National Center for Research Resources (NCRR)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Infant, Newborn\|Infant, Low Birth Weight\|Infant, Small for Gestational Age\|Infant, Premature\|Hypotension\|Blood Pressure	July 2009	Phase 1
NCT03282487	The Adelaide and Meath Hospital, incorporating The National Children´s Hospital	Adrenal Insufficiency	September 5, 2017	Phase 4
NCT03539601	Pfizer	Atopic Dermatitis	April 27, 2018	Phase 4
NCT00682487	Meir Medical Center	Acute Myocardial Infarction	June 2008
NCT00002756	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	June 1996	Phase 2
NCT00002921	Southwest Oncology Group\|National Cancer Institute (NCI)	Adrenocortical Carcinoma	March 1997	Phase 2
NCT00451750	University of Zurich\|University Hospital, Basel, Switzerland	Phobia	May 2007	Not Applicable
NCT01847690	Haukeland University Hospital	Addison Disease	June 2013	Phase 2
NCT00186264	Stanford University\|Wyeth is now a wholly owned subsidiary of Pfizer	Depressive Disorder, Major	August 2002	Not Applicable
NCT01284452	Mahidol University	Septic Shock\|Severe Sepsis\|Acute Lung Injury\|Acute Respiratory Distress Syndrome	December 2010	Not Applicable
NCT02270788	St. Jude Children´s Research Hospital\|Arog Pharmaceuticals, Inc.\|Ohio State University	Acute Myeloid Leukemia	April 2, 2015	Phase 1
NCT00002552	Barbara Ann Karmanos Cancer Institute\|National Cancer Institute (NCI)	Lymphoma\|Multiple Myeloma and Plasma Cell Neoplasm	October 1993	Phase 2
NCT00002865	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Leukemia	April 1995	Phase 2
NCT04546399	National Cancer Institute (NCI)	Down Syndrome\|Recurrent B Acute Lymphoblastic Leukemia	December 4, 2020	Phase 2
NCT02190994	West China Hospital	Pituitary Neoplasms\|Craniopharyngiomas	August 2013	Phase 4
NCT00759005	National Institute on Drug Dependence, China	Heroin Dependence\|Learning and Memory	March 2007	Not Applicable
NCT00362661	University of Zurich	Posttraumatic Stress Disorder	June 2007	Not Applicable
NCT04852458	University of Michigan	Traumatic Birth	May 21, 2021	Phase 1
NCT02230930	University Medical Center Groningen	Parkinson´s Disease\|Apomorphine-induced Skin Reactions	June 2015	Phase 2
NCT00415701	University Hospital Inselspital, Berne	Coronary Artery Disease\|Mitral Valve Regurgitation	November 2006	Phase 4
NCT02775227	Helsinki University Central Hospital	Pancreatic Fistula\|Pancreatic Neoplasms	May 2016	Phase 4
NCT05292664	Andrew E. Place\|AbbVie\|Servier\|Children´s Cancer Research Fund\|University of Colorado, Denver\|Boston Children´s Hospital\|Dana-Farber Cancer Institute	Myelodysplastic Syndromes, de Novo\|Myelodysplastic Syndromes, Secondary\|Myelodysplastic Syndromes, Previously Treated\|Treatment-Related Acute Myeloid Leukemia\|Therapy-Related Myelodysplastic Syndrome\|Acute Lymphoblastic Leukemia, in Relapse\|Acute Lymphoblastic Leukemia With Failed Remission\|Lymphoblastic Lymphoma, in Relapse\|Lymphoblastic Lymphoma, Refractory\|Acute Leukemia of Ambiguous Lineage in Relapse\|Acute Leukemia of Ambiguous Lineage Not Having Achieved Remission	October 2022	Phase 1
NCT04325490	Mahidol University\|HOE pharmaceuticals Sdn. Bhd.	Intertrigo	October 1, 2019	Phase 4
NCT03813147	National Cancer Institute (NCI)\|Children´s Oncology Group	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome\|Recurrent Acute Myeloid Leukemia\|Recurrent Myelodysplastic Syndrome\|Refractory Acute Myeloid Leukemia\|Refractory Myelodysplastic Syndrome	May 1, 2019	Phase 1
NCT02575001	University of Ljubljana, Faculty of Medicine	Type 1 Diabetes\|Stress	July 2015
NCT03832010	Johns Hopkins University\|Pfizer	Atopic Dermatitis\|Eczema	December 17, 2019	Phase 4
NCT03465007	University of Jordan	Dialysis Hypotension	October 22, 2017	Not Applicable
NCT00915343	Shire\|Takeda	Adrenal Insufficiency	August 21, 2007	Phase 2\|Phase 3
NCT00136435	Dana-Farber Cancer Institute\|Brigham and Women´s Hospital\|Massachusetts General Hospital\|Queen Elizabeth II Health Sciences Centre	Acute Lymphoblastic Leukemia	June 2002	Phase 2
NCT03710187	University of Tennessee Medical Center	Septic Shock	November 5, 2018	Phase 2
NCT01108146	Central Institute of Mental Health, Mannheim\|German Research Foundation	Posttraumatic Stress Disorder	October 2008	Not Applicable
NCT02478021	Charite University, Berlin, Germany	Individuality	September 2014	Not Applicable
NCT00899847	Stanford University	Transplantation, Homologous\|Transplantation, Autologous\|Multiple Myeloma\|Blood and Marrow Transplant (BMT)	May 2009	Phase 2
NCT02959580	Peking Union Medical College Hospital	Granulomatous Mastitis	January 1, 2017	Phase 4
NCT04492280	Ain Shams University	Septic Shock	September 1, 2018	Phase 4
NCT00640822	LEO Pharma	Psoriasis Vulgaris	February 2008	Phase 3
NCT00309894	University of California, San Francisco\|National Cancer Institute (NCI)	Prostate Cancer	April 2004	Phase 2
NCT00805285	University of Maryland, Baltimore	Inflammatory Bowel Disease\|Ulcerative Colitis	October 2008	Phase 2
NCT04536129	University of Molise\|Medivis	Ocular Surface Disease\|Glaucoma	November 4, 2019	Not Applicable
NCT00147004	Hadassah Medical Organization\|European Society of Intensive Care Medicine\|International Sepsis Forum\|The Gorham Foundation	Shock, Septic	March 2002	Phase 3
NCT04359147	Charite University, Berlin, Germany	Yohimbine\|Hydrocortisone\|Yohimbine &addition; Hydrocortisone\|Placebo	November 1, 2019	Not Applicable
NCT02229136	US Oncology Research\|Novartis Pharmaceuticals	Stomatitis\|Oral Mucositis\|Neoplasm of the Breast\|Malignant Tumor of Breast	September 4, 2014	Phase 2
NCT00482053	Stanford University	Lymphoma, B-cell\|Lymphoma, Non-Hodgkin\|Diffuse Large B-cell Lymphoma (DLBCL)\|Malignant Lymphoma, Non-Hodgkin	October 2006	Phase 2
NCT00003728	European Organisation for Research and Treatment of Cancer - EORTC\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	December 1998	Phase 3
NCT01867294	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	Advanced Malignant Neoplasm\|Dermatologic Complication	August 31, 2012	Phase 2
NCT00460031	Case Comprehensive Cancer Center	Prostate Cancer	September 1, 2006	Phase 2
NCT02535806	Children´s Mercy Hospital Kansas City\|Millennium Pharmaceuticals, Inc.	Acute Lymphoblastic Leukemia\|Lymphoblastic Lymphoma	July 2015	Phase 2
NCT00473083	British Columbia Cancer Agency\|Hoffmann-La Roche	Rash	January 2009	Phase 2
NCT00320099	University of Versailles\|Assistance Publique - Hôpitaux de Paris	Septic Shock	January 2006	Phase 3
NCT00270777	University of Kelaniya	Snake Bites	March 2005	Phase 4
NCT04896489	Yale University	Alcohol Drinking\|Drinking Behavior\|Episodic Memory\|Long-term Memory	May 12, 2021	Early Phase 1
NCT00003436	Medical Research Council\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes	July 1998	Phase 3
NCT01090518	Bronx VA Medical Center\|Lightfighter Trust	PTSD	February 2010	Not Applicable
NCT00673127	Beth Israel Deaconess Medical Center\|Massachusetts General Hospital\|Dana-Farber Cancer Institute\|Sunnybrook Health Sciences Centre\|Oregon Health and Science University\|M.D. Anderson Cancer Center\|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Prostate Cancer	February 2005	Phase 2
NCT00057811	Children´s Oncology Group\|National Cancer Institute (NCI)	Childhood Burkitt Lymphoma\|Childhood Diffuse Large Cell Lymphoma\|Childhood Immunoblastic Large Cell Lymphoma\|Stage I Childhood Large Cell Lymphoma\|Stage I Childhood Small Noncleaved Cell Lymphoma\|Stage II Childhood Large Cell Lymphoma\|Stage II Childhood Small Noncleaved Cell Lymphoma\|Stage III Childhood Large Cell Lymphoma\|Stage III Childhood Small Noncleaved Cell Lymphoma\|Stage IV Childhood Large Cell Lymphoma\|Stage IV Childhood Small Noncleaved Cell Lymphoma\|Untreated Childhood Acute Lymphoblastic Leukemia	June 2004	Phase 2
NCT00002700	European Organisation for Research and Treatment of Cancer - EORTC\|Acute Leukemia French Association	Leukemia\|Lymphoma	August 1995	Phase 3
NCT01007591	LEO Pharma	Psoriasis Vulgaris	October 2009	Phase 3
NCT03748537	Chiang Mai University	Sepsis\|Septic Shock	January 1, 2017	Not Applicable
NCT02473263	Assistance Publique - Hôpitaux de Paris	Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit	May 9, 2016	Phase 3
NCT00002805	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	August 1997	Phase 2
NCT01954056	NICHD Neonatal Research Network\|National Center for Research Resources (NCRR)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Infant, Newborn, Diseases\|Cardiovascular Insufficiency	June 19, 2014	Phase 3
NCT05167084	Eleonora Seelig\|University Hospital, Basel, Switzerland	Glucocorticoid Effect	February 8, 2022	Early Phase 1
NCT00002970	National Cancer Institute (NCI)\|Children´s Cancer Group	Recurrent Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood Lymphoblastic Lymphoma\|T-cell Childhood Acute Lymphoblastic Leukemia	June 1997	Phase 2
NCT03670212	Wayne State University\|National Institute on Drug Abuse (NIDA)	Cigarette Smoking	January 7, 2016	Phase 1
NCT04469686	Cristcot LLC\|Cristcot HCA LLC	Ulcerative Proctitis	December 10, 2020	Phase 3
NCT01353313	NICHD Neonatal Research Network\|National Center for Research Resources (NCRR)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Heart, Lung, and Blood Institute (NHLBI)\|National Center for Advancing Translational Sciences (NCATS)	Infant, Newborn\|Infant, Small for Gestational Age\|Infant, Very Low Birth Weight\|Infant, Premature\|Bronchopulmonary Dysplasia	August 11, 2011	Phase 3
NCT01559675	Cedars-Sinai Medical Center	Orthostatic Hypotension\|Hemodynamic Instability\|Fever\|Hypothermia	September 2010	Not Applicable
NCT01735617	Diurnal Limited\|National Institutes of Health (NIH)	Endocrine Disease\|Adrenal Insufficiency\|Congenital Adrenal Hyperplasia	December 2012	Phase 2
NCT03936517	Imperial College London\|National Institute for Health Research, United Kingdom\|Imperial Health Charity	Adrenal Insufficiency	July 31, 2019	Phase 3
NCT03371784	Iuliu Hatieganu University of Medicine and Pharmacy\|Romanian Governmental Funding (UEFISCDI)	ST-segment Elevation Myocardial Infarction\|Left Ventricular Remodeling	March 8, 2018	Phase 2\|Phase 3
NCT04148261	Stanford University	Depression	December 2020	Early Phase 1
NCT01230983	Children´s Oncology Group\|National Cancer Institute (NCI)	Cardiac Toxicity\|Leukemia\|Lymphoma	June 1996	Phase 3
NCT03913559	St. Jude Children´s Research Hospital\|Pfizer	Acute Lymphoblastic Leukemia	May 14, 2019	Phase 2
NCT00005802	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Leukemia	June 1999	Phase 1\|Phase 2
NCT00002798	National Cancer Institute (NCI)	Childhood Acute Erythroleukemia (M6)\|Childhood Acute Megakaryocytic Leukemia (M7)\|Childhood Acute Monoblastic Leukemia (M5a)\|Childhood Acute Monocytic Leukemia (M5b)\|Childhood Acute Myeloblastic Leukemia With Maturation (M2)\|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)\|Childhood Acute Myelomonocytic Leukemia (M4)\|Childhood Myelodysplastic Syndromes\|Chronic Myelomonocytic Leukemia\|de Novo Myelodysplastic Syndromes\|Refractory Anemia\|Refractory Anemia With Excess Blasts\|Refractory Anemia With Excess Blasts in Transformation\|Refractory Anemia With Ringed Sideroblasts\|Secondary Myelodysplastic Syndromes\|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies	August 1996	Phase 3
NCT05049473	PETHEMA Foundation\|Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea	Mature B-Cell Leukemia Burkitt Type\|Burkitt Lymphoma (BL)\|Unclassifiable Lymphoma Between DCBL and BL	January 2014	Phase 2
NCT02523664	Charite University, Berlin, Germany	Borderline Personality Disorder\|PTSD	January 2014	Not Applicable
NCT01064986	Rutgers, The State University of New Jersey	Infections	February 2010	Phase 1
NCT00559481	Roswell Park Cancer Institute\|National Cancer Institute (NCI)	Prostate Cancer	October 2007	Not Applicable
NCT04359511	University Hospital, Tours	COVID-19	July 3, 2020	Phase 3
NCT00185783	Stanford University\|University of Toronto\|University of Colorado, Denver	Sepsis\|Relative Adrenal Insufficiency	March 2005
NCT03676933	DS Biopharma	Atopic Dermatitis	October 2015	Phase 2
NCT03760835	Federico II University	Congenital Adrenal Hyperplasia	August 11, 2016	Phase 4
NCT03179813	University of Sao Paulo	Impacted Third Molar Tooth	May 1, 2017	Phase 4
NCT00002785	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	July 1996	Phase 2
NCT00096135	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	November 2004	Not Applicable
NCT00002494	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	May 1992	Phase 2
NCT03209102	Institut National de la Santé Et de la Recherche Médicale, France	Borderline Personality Disorder\|Adolescent Development	October 4, 2017	Phase 2
NCT01828515	University of Texas Southwestern Medical Center\|Forest Laboratories	Memory Impairment	December 2012	Phase 2
NCT03165344	Peking University Third Hospital	Esophageal Stenosis Acquired	February 10, 2017	Not Applicable
NCT05431348	Maastricht Radiation Oncology\|Maastricht University Medical Center	Glioblastoma (GBM)	June 1, 2022
NCT03195933	University of Wisconsin, Madison\|National Institute of Mental Health (NIMH)\|Brain & Behavior Research Foundation	Depression	July 31, 2013	Not Applicable
NCT02735707	UMC Utrecht\|Australian and New Zealand Intensive Care Research Centre\|Medical Research Institute of New Zealand\|Unity Health\|Berry Consultants\|Global Coalition for Adaptive Research\|University of Pittsburgh Medical Center\|Intensive Care National Audit & Research Centre\|St. Marianna University School of Medicine\|National Intensive Care Surveillance MORU	Community-acquired Pneumonia, Influenza, COVID-19	April 11, 2016	Phase 3
NCT03585829	University Tunis El Manar	Corticotropin Deficiency\|Fasting	May 17, 2018	Phase 4
NCT02360046	University Hospital Inselspital, Berne	Hypopituitarism\|Hydrocortisone\|Lipids\|Fatty Acids, Nonesterified\|Insulin Sensitivity	January 2015	Not Applicable
NCT02408939	University of Athens\|University of Thessaly	Infections\|Cardiac Arrest	March 2015
NCT03688789	Rennes University Hospital	Haematological Malignancy	January 1, 2019	Not Applicable
NCT03237689	Johns Hopkins University\|National Institute of Mental Health (NIMH)	Hiv	November 20, 2017	Early Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL ( 85.53 mM )

H ₂ O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.90 mM); Clear solution
2.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 2.5 mg/mL (6.90 mM); Clear solution
3.

Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.90 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution
5.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.
[2] Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.
[3] Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

Synonyms

Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11β)-

Cortisol

(11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

NSC 10483

Anti-inflammatory hormone

Cobadex

Cort-Dome

Cortef

Cortifan

Cortispray

Cortonema

Cortril

Efcorbin

Ficortril

Genacort

Heb-Cort

Hycort

Hycortol

Hycortole

Hydro-Adreson

Hidro-Colisona

Hydrocortisone

Hydrocortisyl

Hydrocortone

17-Hydroxycorticosterone

11β-Hydroxycortisone

Hytone lotion

Incortin-H

Kendall's compound F

Optef

Otosone-F

Permicort

4-Pregnene-11β,17α,21-triol-3,20-dione

Reichstein's substance M

Scheroson F

Tarcortin

Texacort lotion 25

Topicort

Traumaide

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione

11β,17,21-Trihydroxypregn-4-ene-3,20-dione

17α-Hydroxycorticosterone

Domolene-HC

Esiderm H

Epiderm H

Corticreme

Cortiment

Cortanal

Hydrasson

Cortenema

Signef

Hydrocorticosterone

Dihydrocostisone

Polcort H

Efcortelan

Hydrocortal

11β,17,21-Trihydroxyprogesterone

Dermolate

Hytone

U 1851

Hydroskin

CCN 90306A

Acticort

Nutracort

Ala-Cort

Lacticare HC

Zenoxone

Dermacort

Medicort

Synacort

Dioderm

Eldecort

Evacort

Hydracort

Texacort

Penecort

Anflam

CaldeCort Spray

Dermocortal

Timocort

Cetacort

Aeroseb HC

Mildison

Hydrocort

Sanatison

DuoCort

Scalpicin

Hydrocortin

Infacort

Plenadren

Alkindi

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