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[CAS NO. 50-89-5] Thymidine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N1150 |
| Brand: | MCE |
| CAS: | 50-89-5 |
Overview
| MDL | MFCD00006537 |
|---|---|
| Molecular Weight | 242.23 |
| Molecular Formula | C10H14N2O5 |
| SMILES | O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO |
5 Publications Citing Use of MCE
Summary
IC50 & Target
|
Microbial Metabolite
|
DNA Synthesis
|
Human Endogenous Metabolite
|
In Vivo
Thymidine (500 mg/kg; i.p.; twice a day) completely reverses both Methotrexate- and Tomudex-induced deletion of both CD4 + Vβ8 + and CD8 + Vβ8 + T cells [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 8-12 weeks BALB/c mice [3] |
| Dosage: | 500 mg/kg |
| Administration: | i.p.; twice a day |
| Result: | Completely abrogates Methotrexate- and Tomudex-induced deletion of Vβ8 + T cells after SEB injection. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04660435 | Fondazione Sandro Pitigliani|Clinical Research Technology S.r.l. |
Metastatic Breast Cancer|ER Positive Breast Cancer|HER2-negative Breast Cancer
|
September 1, 2020 | |
| NCT00005025 | John Stoddard Cancer Center at Iowa Methodist Medical Center|National Cancer Institute (NCI) |
Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
|
June 2000 | Phase 2 |
| NCT00004658 | National Center for Research Resources (NCRR)|University of California, San Diego|Office of Rare Diseases (ORD) |
5´-Nucleotidase Syndrome
|
March 1995 | Phase 2 |
| NCT03639701 | Columbia University|Muscular Dystrophy Association|Hospital Universitario 12 de Octubre|Instituto de Salud Carlos III|University of Seville|Medical Research Council Mitochondrial Biology Unit|Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER), Spain|Hospitales Universitarios Virgen del Rocío|Universitat Autonoma de Barcelona |
Mitochondrial DNA Depletion Syndrome 2 Myopathic Type|Thymidine Kinase 2 Deficiency
|
May 16, 2017 | Phase 1|Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 206.42 mM ; Need ultrasonic)
H 2 O : 33.33 mg/mL ( 137.60 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.1283 mL | 20.6415 mL | 41.2831 mL |
| 5 mM | 0.8257 mL | 4.1283 mL | 8.2566 mL |
| 10 mM | 0.4128 mL | 2.0642 mL | 4.1283 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 20 mg/mL (82.57 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).
- [2] FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.
- [3] Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13(1):85-93.
Synonyms
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