[CAS NO. 500-64-1] (+)-Kavain

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PRODUCTS SPECIFICATIONS [500-64-1]

Catalog

HY-B1671

Brand

MCE

CAS

500-64-1

DESCRIPTION [500-64-1]

Overview

MDL	MFCD00467093
Molecular Weight	230.26
Molecular Formula	C14H14O3
SMILES	O=C1C=C(OC)C[C@H](/C=C/C2=CC=CC=C2)O1

For research use only. We do not sell to patients.

Summary

(+)-Kavain, a main kavalactone extracted from Piper methysticum , has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels ^[1] . (+)-Kavain is shown to bind at the α4β2δ GABA _A receptor and potentiate GABA efficacy ^[2] . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied ^[4] .

IC50 & Target

Na ⁺ , Ca ²⁺ channel ^[1] .
α4β2δ GABA _A receptor ^[2] .

In Vitro

(+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM ^[2] . (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 217.15 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3429 mL	21.7146 mL	43.4292 mL
5 mM	0.8686 mL	4.3429 mL	8.6858 mL
10 mM	0.4343 mL	2.1715 mL	4.3429 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-, (6R)-

2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (R)-

2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, [R-(E)]-

(6R)-5,6-Dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one

Gonosan

Kawain

(+)-Kavain

Kavain

d-Kawain

NSC 112162

(R)-(+)-Kavain

(+)-Kawain