[CAS NO. 5003-48-5] Benorilate

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PRODUCTS SPECIFICATIONS [5003-48-5]

Catalog

HY-107795

Brand

MCE

CAS

5003-48-5

DESCRIPTION [5003-48-5]

Overview

MDL	MFCD00864257
Molecular Weight	313.30
Molecular Formula	C17H15NO5
SMILES	O=C(OC1=CC=C(NC(C)=O)C=C1)C2=CC=CC=C2OC(C)=O

For research use only. We do not sell to patients.

Summary

Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

Prostaglandin ^[4] .

In Vitro

Benorylate (Salipran) is an esterified aspirin preparation whose antirheumatic properties are reported to be as good as those of aspirin ^[1] .
Benorylate (Salipran) causes a large decrease in the liver’s conversion rate of lactate into glucose, an important component of glucose homeostasis. Benorylate (Salipran) also impairs the urea synthesis rate from ammonia, another important function of the liver ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benorylate (Salipran) is probably absorbed as the intact molecule which accounts for its good gastric tolerance ^[3] .
Benorylate (Salipran) could inhibit PG synthesis in laboratory animals and in human tissue ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 398.98 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1918 mL	15.9591 mL	31.9183 mL
5 mM	0.6384 mL	3.1918 mL	6.3837 mL
10 mM	0.3192 mL	1.5959 mL	3.1918 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester

Salicylic acid acetate, ester with 4′-hydroxyacetanilide

Acetanilide, 4′-hydroxy-, salicylate (ester) acetate (ester)

p-Acetamidophenyl acetylsalicylate

4-Acetamidophenyl 2-acetoxybenzoate

4-Acetaminophenyl 2-acetoxybenzoate

Benorylate

Aspirin acetaminophen ester

Fenasprate

Benoral

Acetylsalicylic acid paracetamol ester

p-N-Acetylaminophenyl acetylsalicylate

Benorilate

Win 11450

TO 125

Benortan

Quinexin

Salipran