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[CAS NO. 501-97-3] Desaminotyrosine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W015346 |
| Brand: | MCE |
| CAS: | 501-97-3 |
Overview
| MDL | MFCD00002778 |
|---|---|
| Molecular Weight | 166.18 |
| Molecular Formula | C9H10O3 |
| SMILES | C1=C(C=CC(=C1)O)CCC(O)=O |
Summary
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
IC50 & Target
|
Microbial Metabolite
|
Human Endogenous Metabolite
|
In Vivo
Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Saccharomyces cerevisiae
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 601.76 mM ; Need ultrasonic)
H 2 O : 33.33 mg/mL ( 200.57 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.0176 mL | 30.0879 mL | 60.1757 mL |
| 5 mM | 1.2035 mL | 6.0176 mL | 12.0351 mL |
| 10 mM | 0.6018 mL | 3.0088 mL | 6.0176 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (601.76 mM); Clear solution; Need ultrasonic
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2.
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3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
Synonyms
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