[CAS NO. 501698-03-9]  GDP366

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PRODUCTS SPECIFICATIONS [501698-03-9]

Catalog
HY-U00177
Brand
MCE
CAS
501698-03-9

DESCRIPTION [501698-03-9]

Overview

MDLMFCD31544386
Molecular Weight375.45
Molecular FormulaC20H17N5OS
SMILESO=C(NC1=CC=CC(C)=C1)NC2=CC=C(C3=CSC4=NC=NC(N)=C43)C=C2

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

GDP366, a dual inhibitor of survivin and Op18 , induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.


IC50 & Target

Survivin [1]
Op18 [1]


In Vitro

GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 166.47 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6635 mL 13.3174 mL 26.6347 mL
5 mM 0.5327 mL 2.6635 mL 5.3269 mL
10 mM 0.2663 mL 1.3317 mL 2.6635 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

* All of the co-solvents are available by MCE.