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[CAS NO. 501698-03-9] GDP366
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-U00177 |
| Brand: | MCE |
| CAS: | 501698-03-9 |
Overview
| MDL | MFCD31544386 |
|---|---|
| Molecular Weight | 375.45 |
| Molecular Formula | C20H17N5OS |
| SMILES | O=C(NC1=CC=CC(C)=C1)NC2=CC=C(C3=CSC4=NC=NC(N)=C43)C=C2 |
1 Publications Citing Use of MCE
Summary
In Vitro
GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 166.47 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6635 mL | 13.3174 mL | 26.6347 mL |
| 5 mM | 0.5327 mL | 2.6635 mL | 5.3269 mL |
| 10 mM | 0.2663 mL | 1.3317 mL | 2.6635 mL |
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