[CAS NO. 506-23-0] α-Eleostearic acid

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PRODUCTS SPECIFICATIONS [506-23-0]

Catalog

HY-27787

Brand

MCE

CAS

506-23-0

DESCRIPTION [506-23-0]

Overview

MDL	-
Molecular Weight	278.43
Molecular Formula	C18H30O2
SMILES	CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O

For research use only. We do not sell to patients.

Summary

α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity ^[1] ^[2] ^[3] .

In Vitro

α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma ^[1] .
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells ^[1] .
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-Eleostearic acid (0.5% of total lipid given; p.o.) inhibits Sodium Arsenite-induced oxidative stress, including reversal of antioxidant enzyme activity and reduction of lipid peroxidation levels ^[2] .
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.