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[CAS NO. 506-23-0] α-Eleostearic acid
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-27787 |
| Brand: | MCE |
| CAS: | 506-23-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 278.43 |
| Molecular Formula | C18H30O2 |
| SMILES | CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O |
Summary
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity [1] [2] [3] .
In Vitro
α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma
[1]
.
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells
[1]
.
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
α-Eleostearic acid (0.5% of total lipid given; p.o.) inhibits Sodium Arsenite-induced oxidative stress, including reversal of antioxidant enzyme activity and reduction of lipid peroxidation levels
[2]
.
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Kobori M, et, al. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J Agric Food Chem. 2008 Nov 26;56(22):10515-20.
- [2] Saha SS, et, al. Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. Food Chem Toxicol. 2009 Oct;47(10):2551-6.
- [3] Beatty A, et, al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244.
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