[CAS NO. 509102-00-5] MIM1
PRODUCTS SPECIFICATIONS [509102-00-5]
DESCRIPTION [509102-00-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 347.43 |
| Molecular Formula | C17H21N3O3S |
| SMILES | OC1=C(O)C(/C=N/N2/C(SC=C2C)=N/C3CCCCC3)=CC=C1O |
Summary
MIM-1 is an inhibitor of myeloid cell factor 1 ( Mcl-1 ).
IC50 & Target
|
Mcl-1 |
In Vitro
MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC 50 value. The IC 50 value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC 50 of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 143.91 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8783 mL | 14.3914 mL | 28.7828 mL |
| 5 mM | 0.5757 mL | 2.8783 mL | 5.7566 mL |
| 10 mM | 0.2878 mL | 1.4391 mL | 2.8783 mL |
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Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.99 mM); Suspended solution