[CAS NO. 51-24-1] Tiratricol

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PRODUCTS SPECIFICATIONS [51-24-1]

Catalog

HY-B1201

Brand

MCE

CAS

51-24-1

DESCRIPTION [51-24-1]

Overview

MDL	MFCD00055931
Molecular Weight	621.93
Molecular Formula	C14H9I3O4
SMILES	O=C(O)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1

For research use only. We do not sell to patients.

Summary

Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05579327	Rare Thyroid Therapeutics International AB\|Premier Research Group plc\|Egetis Therapeutics	Monocarboxylate Transporter 8 Deficiency	November 2022	Phase 3

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 42 mg/mL ( 67.53 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6079 mL	8.0395 mL	16.0790 mL
5 mM	0.3216 mL	1.6079 mL	3.2158 mL
10 mM	0.1608 mL	0.8039 mL	1.6079 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Benzeneacetic acid, 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-

Thyroacetic acid, 3,3′,5-triiodo-

Acetic acid, [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-

4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid

3,3′,5-Triiodothyroacetic acid

Triac

[(4-Hydroxy-3-iodo-4-phenoxy)-3,5-diiodophenyl]acetic acid

T₃A

Triacana

Tiratricol

Nidolin

2-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid