[CAS NO. 511296-88-1] Pifithrin-βhydrobromide

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PRODUCTS SPECIFICATIONS [511296-88-1]

Catalog

HY-16702A

Brand

MCE

CAS

511296-88-1

DESCRIPTION [511296-88-1]

Overview

MDL	MFCD02683960
Molecular Weight	349.29
Molecular Formula	C16H17BrN2S
SMILES	CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1.Br

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC ₅₀ of 23 μM.

IC50 & Target

IC50: 23 μM (p53) ^[1]

In Vitro

Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative ^[2] . After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 28.63 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8630 mL	14.3148 mL	28.6295 mL
5 mM	0.5726 mL	2.8630 mL	5.7259 mL
10 mM	0.2863 mL	1.4315 mL	2.8630 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (2.86 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (2.86 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (2.86 mM); Clear solution

* All of the co-solvents are available by MCE.