[CAS NO. 515-13-9] β-Elemene
PRODUCTS SPECIFICATIONS [515-13-9]
DESCRIPTION [515-13-9]
Overview
| MDL | MFCD00468041 |
|---|---|
| Molecular Weight | 204.35 |
| Molecular Formula | C15H24 |
| SMILES | CC([C@H]1[C@@](C)(CC[C@@H](C(C)=C)C1)C=C)=C |
1 Publications Citing Use of MCE
Summary
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis .
In Vitro
β-Elemene (0-200 µg/ml; 24 hours) shows IC
50
values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively
[1]
.
β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml, induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase
[1]
.
β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells
[1]
.
β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [2]
| Cell Line: | T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells |
| Concentration: | 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. |
Cell Cycle Analysis [2]
| Cell Line: | T24 and 5637 cells |
| Concentration: | 0, 25, 50 and 75 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Induced the percentage of cells in the S-phase as a dose-dependent manner. |
Western Blot Analysis [2]
| Cell Line: | T24 cells |
| Concentration: | 50 µg/ml |
| Incubation Time: | 24 hours |
| Result: | Downregulated p-STAT3 and cell cycle-related proteins. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02629757 | Sun Yat-sen University |
Anaplastic Oligoastrocytoma|Anaplastic Astrocytoma|Glioblastoma
|
April 2015 | Phase 3 |
| NCT03123484 | China Medical University, China|The First Affiliated Hospital of Dalian Medical University|The Second Affiliated Hospital of Dalian Medical University|Liaoning Tumor Hospital & Institute|Shengjing Hospital|General Hospital of Shenyang Military Region |
Non Small Cell Lung Cancer
|
April 2017 | Phase 2 |
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
Ethanol : 50 mg/mL ( 244.68 mM ; Need ultrasonic)
DMSO : 50 mg/mL ( 244.68 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.8936 mL | 24.4678 mL | 48.9356 mL |
| 5 mM | 0.9787 mL | 4.8936 mL | 9.7871 mL |
| 10 mM | 0.4894 mL | 2.4468 mL | 4.8936 mL |
References
- [1] Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996).
- [2] Gan D, et al. β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway.Oncol Lett. 2020 Jan;19(1):291-300.
Synonyms