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[CAS NO. 51543-39-6] (S)-Flurbiprofen
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-15123 |
| Brand: | MCE |
| CAS: | 51543-39-6 |
Overview
| MDL | MFCD00866152 |
|---|---|
| Molecular Weight | 244.26 |
| Molecular Formula | C15H13FO2 |
| SMILES | O=C(O)[C@@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1 |
Summary
IC50 & Target
|
COX-1 0.48 μM (IC 50 ) |
COX-2 0.47 μM (IC 50 ) |
In Vitro
(S)-Flurbiprofen (10 –7 M) results in a total suppression of basal and stimulated PGE2 release in rat skin [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03434197 | Taisho Pharmaceutical Co., Ltd. |
Osteoarthritis Knee Pain
|
February 5, 2018 | Phase 3 |
| NCT04908748 | Teikoku Seiyaku Co., Ltd.|Clinsearch GmbH|CRM Biometrics GmbH|Clinigen GmbH |
Soft Tissue Injuries|Contusions|Strains|Sprains|Bruises
|
May 20, 2021 | Phase 2 |
| NCT02729207 | Teikoku Seiyaku Co., Ltd. |
Ankle Sprain
|
July 2016 | Phase 2 |
| NCT04505787 | SocraTec R&D GmbH|Teikoku Seiyaku Co., Ltd.|SocraMetrics GmbH |
Comparative Bioavailability
|
July 24, 2020 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 409.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0940 mL | 20.4700 mL | 40.9400 mL |
| 5 mM | 0.8188 mL | 4.0940 mL | 8.1880 mL |
| 10 mM | 0.4094 mL | 2.0470 mL | 4.0940 mL |
References
- [1] A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36(6):505-12.
- [2] B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S(+)-flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52(12):519-23.
Synonyms
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