[CAS NO. 516-05-2] Methylmalonic acid
PRODUCTS SPECIFICATIONS [516-05-2]
DESCRIPTION [516-05-2]
Overview
| MDL | MFCD00002656 |
|---|---|
| Molecular Weight | 118.09 |
| Molecular Formula | C4H6O4 |
| SMILES | O=C(O)C(C)C(O)=O |
Summary
Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Vitamin B-12 is required for Methylmalonate (Methylmalonic acid; MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine. Therefore, Methylmalonate is clearly more specific to vitamin B-12 deficiency compared to HC [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT05352737 | KU Leuven |
Breast Cancer
|
January 22, 2021 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 846.81 mM ; Need ultrasonic)
H 2 O : 100 mg/mL ( 846.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 8.4681 mL | 42.3406 mL | 84.6812 mL |
| 5 mM | 1.6936 mL | 8.4681 mL | 16.9362 mL |
| 10 mM | 0.8468 mL | 4.2341 mL | 8.4681 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (846.81 mM); Clear solution; Need ultrasonic
-
2.
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3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (21.17 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (21.17 mM); Clear solution
Synonyms