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[CAS NO. 516480-79-8] BML-277
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-13946 |
| Brand: | MCE |
| CAS: | 516480-79-8 |
Overview
| MDL | MFCD08276917 |
|---|---|
| Molecular Weight | 363.80 |
| Molecular Formula | C20H14ClN3O2 |
| SMILES | ClC(C=C1)=CC=C1OC(C=C2)=CC=C2C3=NC4=CC(C(N)=O)=CC=C4N3 |
3 Publications Citing Use of MCE
Summary
BML-277 is a selective checkpoint kinase 2 ( Chk2 ) inhibitor with an IC 50 of 15 nM.
IC50 & Target
|
Chk2 15 nM (IC 50 ) |
In Vitro
BML-277 is an ATP-competitive inhibitor of Chk2 that dose dependently protects human CD4 + and CD8 + T-cells from apoptosis due to ionizing radiation. BML-277 efficiently rescues both T-cell populations from radiation-induced apoptosis in a dose-dependent manner with an observed EC 50 of 3−7.6 μM. The concentration of BML-277 required for radioprotection is consistent with the biochemical measurement of chk2 inhibition. Providing theK m of ATP for Chk2 is determined to be 99 μM and the K i for BML-277 is 37 nM, and assuming that the intracellular ATP concentration is 10 mM, a 5 μM concentration of BML-277 would be expected to produce 42% inhibition of intracellular chk2 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 22.22 mg/mL ( 61.08 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7488 mL | 13.7438 mL | 27.4876 mL |
| 5 mM | 0.5498 mL | 2.7488 mL | 5.4975 mL |
| 10 mM | 0.2749 mL | 1.3744 mL | 2.7488 mL |
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