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[CAS NO. 518-69-4] Corydaline
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N0923 |
| Brand: | MCE |
| CAS: | 518-69-4 |
Overview
| MDL | MFCD00076019 |
|---|---|
| Molecular Weight | 369.45 |
| Molecular Formula | C22H27NO4 |
| SMILES | C[C@@H](C1=CC=C2OC)[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC |
Summary
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo , is an AChE inhibitor with an IC 50 of 226 µM. Corydaline is a μ-opioid receptor ( K i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication ( IC 50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities [1] [2] [3] .
IC50 & Target
|
AChE
|
μ Opioid Receptor/MOR
|
In Vitro
Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro
[2]
.
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [2]
| Cell Line: | Vero cells infected with EV71 |
| Concentration: | 12.5 µM, 25 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2. |
In Vivo
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid [3] |
| Dosage: | 10 mg/kg |
| Administration: | Subcutaneous administration; once |
| Result: | Showed antinociceptive effects in mice. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 90.22 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7067 mL | 13.5336 mL | 27.0673 mL |
| 5 mM | 0.5413 mL | 2.7067 mL | 5.4135 mL |
| 10 mM | 0.2707 mL | 1.3534 mL | 2.7067 mL |
-
1.
References
- [1] Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.
- [2] Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133.
- [3] Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804.
Synonyms
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