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[CAS NO. 52-01-7] Spironolactone

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Catalog:	HY-B0561
Brand:	MCE
CAS:	52-01-7

Overview

MDL	-
Molecular Weight	416.57
Molecular Formula	C24H32O4S
SMILES	C[C@@]12[C@](OC3=O)(CC3)CC[C@@]1([H])[C@@]([C@@H](CC4=CC5=O)SC(C)=O)([H])[C@]([C@]4(CC5)C)([H])CC2

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

[1]Circulation. 2022 Oct 4;146(14):1082-1095.
[2]J Healthc Eng. 16 Dec 2021.

Summary

Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC ₅₀ of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC ₅₀ of 77 nM. Spironolactone promotes autophagy in podocytes ^[1] ^[2] ^[3] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00604006	Monash University\|National Heart Foundation, Australia	Heart Failure	September 2008	Phase 3
NCT01897727	University of Alabama at Birmingham\|National Heart, Lung, and Blood Institute (NHLBI)	Obstructive Sleep Apnea\|Resistant Hypertension\|Hyperaldosteronism	January 2009	Not Applicable
NCT01195805	Regional Hospital Holstebro	Essential Hypertension	August 2010	Not Applicable
NCT02253394	Brigham and Women´s Hospital\|Gilead Sciences	Pulmonary Arterial Hypertension	September 2015	Phase 4
NCT00276289	Indiana University School of Medicine\|Indiana University	Idiopathic Hypercalciuria\|Hypokalemia Caused by Thiazide Diuretics	January 2006	Not Applicable
NCT04327232	National University Hospital, Singapore\|University of Otago	Atrial Fibrillation	May 23, 2018	Phase 2
NCT01083290	Orion Corporation, Orion Pharma	Healthy	April 2010	Phase 1
NCT00226109	University of Aarhus	Cardiomyopathy, Alcoholic\|Alcoholism	April 2004	Phase 4
NCT00857909	Regional Hospital Holstebro	High Blood Pressure	January 2009	Phase 1
NCT01853553	University of Colorado, Denver\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	ADPKD	July 2013	Phase 3
NCT03744767	Dr Irmela MANTEL\|Eye Hospital Jules Gonin	Neovascular Age-related Macular Degeneration	September 19, 2014	Phase 2
NCT03929718	Piedmont Healthcare	AFib	April 24, 2019	Early Phase 1
NCT00709137	VA Salt Lake City Health Care System	Hypertension	October 2008	Not Applicable
NCT02502981	University Hospital Birmingham\|Royal Free Hospital NHS Foundation Trust\|University of Edinburgh\|University of Cambridge	Renal Insufficiency, Chronic\|Cardio-Renal Syndrome	June 2014	Phase 4
NCT00865501	University of Erlangen-Nürnberg Medical School	Primary Hypertension	March 2008	Phase 3
NCT00211081	Emory University	Congenital Disorders	November 2004	Not Applicable
NCT02901184	Uppsala University\|Karolinska University\|Duke Clinical Research Institute\|National Heart, Lung, and Blood Institute (NHLBI)	Heart Failure With Preserved Ejection Fraction	November 23, 2017	Phase 3
NCT02354352	Ohio State University\|University of California, Los Angeles\|University of Utah\|University of Colorado, Denver\|University of Kansas Medical Center\|Vanderbilt University Medical Center	Duchenne Muscular Dystrophy	March 20, 2015	Phase 3
NCT01314898	Pfizer	Healthy Volunteers	March 2011	Phase 1
NCT00664222	Tottori University Hospital	Chronic Stable Heart Failure	January 2004	Phase 4
NCT00865124	Brigham and Women´s Hospital\|National Institutes of Health (NIH)\|National Heart, Lung, and Blood Institute (NHLBI)	Type 2 Diabetes Mellitus\|Vascular Disease	September 2008	Not Applicable
NCT04465123	Chiang Mai University	Acute Heart Failure\|Acute Kidney Injury	August 13, 2020	Phase 3
NCT00317954	Steno Diabetes Center Copenhagen	Diabetic Nephropathy	September 2003	Phase 4
NCT03682497	AstraZeneca	Heart Failure	November 1, 2018	Phase 1
NCT03068910	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Hyperandrogenism\|Polycystic Ovary Syndrome\|Puberty	July 21, 2016	Early Phase 1
NCT00206232	Baylor College of Medicine	Heart Failure	July 2004	Phase 4
NCT02429388	The University of Texas Health Science Center at San Antonio	Heart Failure	May 2014	Phase 4
NCT03291145	Herlev and Gentofte Hospital	Long Qt Syndrome 1-2\|Sudden Cardiac Death	June 27, 2017	Not Applicable
NCT02483195	University of Florida	Female Androgenetic Alopecia	August 2016	Phase 4
NCT03551548	University Hospital, Caen\|Ministry of Health, France	Cardiac Surgery\|Atrial Fibrillation\|Aldosterone Blockade	February 26, 2019	Phase 3
NCT00381134	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Diabetes\|Kidney Disease\|Hypertension	July 2003	Phase 2
NCT01691053	Wuerzburg University Hospital\|German Federal Ministry of Education and Research\|Clinical Trial Center Wuerzburg (CTCW)	End Stage Renal Disease + Hemodialysis	December 2012	Phase 2
NCT04826822	Chita State Regional Clinical Hospital Number 1	Coronavirus Infection\|Pneumonia, Viral	February 24, 2021	Phase 3
NCT01371747	Relypsa, Inc.\|Vifor Pharma	Chronic Kidney Disease\|Hypertension\|Hyperkalemia	June 2011	Phase 2
NCT03984591	Bispebjerg Hospital\|Rigshospitalet, Denmark	Systolic Heart Failure	November 1, 2020	Phase 4
NCT01198496	Biomedis International Ltd.	Hypertension\|Stroke\|Blood Pressure	October 2010	Phase 4
NCT04853355	Wake Forest University Health Sciences	Diabetic Maculopathy	July 2022	Phase 4
NCT03174288	University of Virginia\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Type 1 Diabetes	August 2015	Not Applicable
NCT03048825	Population Health Research Institute\|Canadian Institutes of Health Research (CIHR)\|Boston Scientific Corporation	ST Elevation Myocardial Infarction\|Non ST Elevation Myocardial Infarction	February 1, 2018	Phase 3
NCT02053974	TC Erciyes University	Anthracycline Induced Cardiotoxicity	September 2011	Phase 4
NCT02823626	The University of Texas Health Science Center at San Antonio\|Relypsa, Inc.	Acute Decompensated Heart Failure	September 2016
NCT05010707	Washington University School of Medicine	Transgenderism	August 2, 2021	Phase 3
NCT00811486	University of Colorado, Denver	Right Heart Failure\|Pulmonary Hypertension	January 2009	Not Applicable
NCT01867294	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	Advanced Malignant Neoplasm\|Dermatologic Complication	August 31, 2012	Phase 2
NCT01388088	Erling Bjerregaard Pedersen\|Regional Hospital Holstebro	Hypertension	September 2010	Phase 4
NCT00663195	Tottori University Hospital	Chronic Stable Heart Failure	January 2004	Phase 4
NCT00773084	Texas Tech University Health Sciences Center	Diastolic Heart Failure	September 2008	Not Applicable
NCT01552044	Institut National de la Santé Et de la Recherche Médicale, France	Central Serous Chorioretinitis	January 2012	Phase 1\|Phase 2
NCT01843309	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran	Patients With Fungic Infections	May 2013	Phase 4
NCT01602861	Odense University Hospital\|Fredericia Hosptial	Disorder Related to Renal Transplantation	February 2013	Phase 4
NCT00498537	US Department of Veterans Affairs\|VA Office of Research and Development	Diabetic Nephropathy	January 2003	Not Applicable
NCT00328809	State University of New York - Upstate Medical University	End Stage Renal Disease\|Congestive Heart Failure	June 30, 2013	Phase 4
NCT00335413	Steno Diabetes Center Copenhagen	Hypertension	June 2006	Phase 4
NCT00429897	University of Cambridge\|British Heart Foundation	Low-Renin Hypertension	August 2006	Not Applicable
NCT00292162	NHS Greater Glasgow and Clyde	Chronic Heart Failure\|Atrial Fibrillation	January 2007	Not Applicable
NCT01721655	West Virginia University Healthcare	Chronic Lung Disease\|Bronchopulmonary Dysplasia	October 2012	Phase 2\|Phase 3
NCT01103245	Vanderbilt University Medical Center	Metabolic Diseases\|Diabetes Mellitus\|Endocrine System Diseases\|Glucose Metabolism Disorders	March 2010	Phase 1
NCT04582383	University of Pennsylvania	Acne	March 30, 2022	Phase 4
NCT00001202	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Institutes of Health Clinical Center (CC)	Precocious Puberty	January 1985	Phase 2
NCT00125437	Hebei Medical University	Heart Failure, Congestive	September 2005	Not Applicable
NCT02236520	Vanderbilt University\|American Heart Association\|Vanderbilt University Medical Center	Hypertension	September 2014	Phase 2
NCT04760717	Yale University\|American Heart Association	Intracerebral Hemorrhage\|Spironolactone	March 19, 2021	Phase 2
NCT05394142	Fundació Sant Joan de Déu	Polycystic Ovary Syndrome (PCOS)	May 24, 2022	Phase 2
NCT03344159	Ottawa Heart Institute Research Corporation	Chronic Right-Sided Heart Failure\|Pulmonary Arterial Hypertension\|Pulmonary Hypertension, Primary, 2\|Pulmonary Hypertension, Primary, 3\|Pulmonary Hypertension, Primary, 4\|Cardiomyopathy Right Ventricular	April 1, 2018	Phase 4
NCT04727073	Charite University, Berlin, Germany\|Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)\|Echo Core Lab Berlin\|University of Göttingen\|University Medicine Greifswald\|Ludwig-Maximilians - University of Munich\|Institute for Cardiovascular Computer-assisted Medicine, Charité\|Coordinating Centre for Clinical Trials, Charité	Heart Failure With Mid-range Ejection Fraction\|Heart Failure With Preserved Ejection Fraction	November 1, 2018	Phase 3
NCT01488877	Pfizer	Type 2 Diabetic Nephropathy	January 2012	Phase 1
NCT00123955	Wake Forest University\|National Institute on Aging (NIA)\|Wake Forest University Health Sciences	Diastolic Heart Failure\|Heart Failure, Congestive	April 2005	Phase 3
NCT02417896	Instituto Nacional de Cardiologia Ignacio Chavez\|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran	Acute Kidney Injuries\|Kidney Injuries, Acute\|Kidney Injury, Acute\|Acute Renal Injury\|Acute Renal Injuries	April 2013	Not Applicable
NCT05230901	University Medical Center Goettingen	Aortic Stenosis, Severe	February 23, 2022	Phase 3
NCT02575963	Actinium Pharmaceuticals	AML	October 2012	Phase 1\|Phase 2
NCT01062763	Ib Abildgaard Jacobsen\|Odense University Hospital	Arterial Hypertension\|Hypertension, Resistant to Conventional Therapy\|Diabetes Mellitus	March 2010	Phase 3
NCT00094302	HealthCore-NERI\|National Heart, Lung, and Blood Institute (NHLBI)	Cardiovascular Diseases\|Heart Diseases\|Heart Failure, Congestive	August 2006	Phase 3
NCT03071263	Relypsa, Inc.\|Vifor Pharma	Hyperkalemia\|Resistant Hypertension	January 23, 2017	Phase 2
NCT02497300	University of Alabama at Birmingham\|National Institutes of Health (NIH)	Chronic Kidney Disease\|Albuminuria	March 2015	Phase 2
NCT01407471	Assistance Publique - Hôpitaux de Paris\|Société de Dermatologie Française	Cutaneous Atrophy Due to Corticosteroids	September 2011	Phase 2
NCT04676646	AstraZeneca	Hyperkalaemia\|Heart Failure With Reduced Ejection Fraction	March 8, 2021	Phase 4
NCT00430794	Sheffield Teaching Hospitals NHS Foundation Trust\|University of Sheffield	Hypertension	March 2007	Phase 2
NCT02764619	Svendborg Hospital\|Region of Southern Denmark\|Takeda	Atrial Fibrillation	December 2013	Phase 3
NCT01294319	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Institutes of Health Clinical Center (CC)	Cortisol Resistance\|Negative Feedback\|ACTH\|Mineralcorticoid\|Glucocorticoid	January 24, 2011	Phase 2
NCT03626506	Peking University Third Hospital\|University of Michigan\|Peking University	Hypertension	February 13, 2019	Not Applicable
NCT02883400	Wake Forest University Health Sciences	Transplant, Liver	December 2014	Phase 4
NCT02369081	University of Cambridge\|British Heart Foundation	Hypertension, Resistant to Conventional Therapy	May 2009	Phase 4
NCT03593317	Hospices Civils de Lyon	Arrhythmogenic Right Ventricular Dysplasia	September 2022	Phase 2
NCT00188045	University Hospital, Angers	Alcoholic Cirrhosis	April 1995	Phase 4
NCT02378805	University Hospital Goettingen\|Society for Pediatric Nephrology (Germany)\|Deutsche Gesellschaft für Nephrologie\|Alport Selbsthilfe e.V.\|Association pour l´Information et la Recherche sur les Maladies Rénales Génétiques (AIRG)\|KfH Foundation Preventive Medicine	Alport Syndrome\|Hereditary Kidney Disease\|Pediatric Kidney Disease\|Thin Basement Membrane Disease\|Familial Benign Hematuria	July 1995
NCT00004311	National Center for Research Resources (NCRR)\|Baylor College of Medicine\|Office of Rare Diseases (ORD)	Acanthosis Nigricans\|Polycystic Ovary Syndrome	July 1989	Phase 2
NCT00870402	Universidad de los Andes, Chile	Diabetic Nephropathy	March 2009	Phase 4
NCT02285920	University of Pennsylvania\|Brigham and Women´s Hospital\|George Washington University\|Vanderbilt University\|University of Washington	End-Stage Renal Disease	November 2014	Phase 2
NCT03953209	Medical University of South Carolina	Melasma	March 5, 2020	Phase 1
NCT02040441	Peter Rossing\|Mosaiques Diagnostics GmbH\|University Medical Center Groningen\|University of Glasgow\|Istituto Di Ricerche Farmacologiche Mario Negri\|Univerzita Karlova v Praze\|Geniko Nosokomeio Athinas Ippokrateio\|Institut Klinické a Experimentální Mediciny Praze\|Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz\|Klinikum St. Georg Leipzig\|Cyril and Methodius University in Skopje\|Hannover Clinical Trial Center\|European Commission\|Diabetes Vascular Research Foundation Hoogeveen\|Universitair Ziekenhuis Gent\|Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden\|Stichting VUMC\|Diabetologen Hessen\|Steno Diabetes Center Copenhagen	Diabetic Nephropathy\|Diabetic Retinopathy	March 2014	Phase 2\|Phase 3
NCT04075149	University of Virginia\|Waterloo Foundation	Polycystic Ovary Syndrome\|Puberty Disorders\|Ovulation Disorder	December 18, 2019	Early Phase 1
NCT01973335	Hasselt University\|Ziekenhuis Oost-Limburg\|Universitaire Ziekenhuizen KU Leuven	Heart Failure	November 2013	Phase 4
NCT01687699	Dialysis Outcomes Heart Failure Aldactone Study Group	End-stage Renal Failure	April 2008	Phase 4
NCT00175617	University of British Columbia	Female Pattern Hair Loss	September 2005	Phase 2
NCT02235077	Duke University\|National Heart, Lung, and Blood Institute (NHLBI)	Heart Failure	December 30, 2014	Phase 2
NCT05501080	Second Affiliated Hospital of Nanchang University	Primary Aldosteronism	September 1, 2022	Not Applicable
NCT00277693	Universidad de los Andes, Chile	Hemodialysis		Phase 4
NCT02299726	Indiana University\|National Heart, Lung, and Blood Institute (NHLBI)\|Vanderbilt University\|Wayne State University	Acute Heart Failure	May 2015	Phase 2
NCT00141778	Vanderbilt University\|National Heart, Lung, and Blood Institute (NHLBI)	Atrial Fibrillation	April 2005	Phase 2\|Phase 3
NCT00574119	Vanderbilt University\|Vanderbilt University Medical Center	Heart Failure\|Nonischemic Dilated Cardiomyopathy	December 2007	Phase 4
NCT03020303	Population Health Research Institute\|Canadian Institutes of Health Research (CIHR)	Endstage Renal Disease	July 7, 2017	Phase 3
NCT04367051	Asan Medical Center	Heart Failure	August 13, 2020	Not Applicable
NCT04345887	Istanbul University-Cerrahpasa	Respiratory Distress Syndrome, Adult	May 5, 2020
NCT02948998	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine\|Ruijin Hospital\|RenJi Hospital\|Shanghai Jiao Tong University Affiliated Sixth People´s Hospital	Hypertrophic Cardiomyopathy\|Fibrosis	May 14, 2018	Phase 4
NCT04205136	University of Michigan	Obstructive Sleep Apnea	March 2022	Phase 4
NCT01586442	Montreal Heart Institute\|Pfizer	Heart Failure\|Type 2 Diabetes\|Glucose Intolerance	March 2012	Phase 3
NCT02531412	Instituto Nacional de Cancerologia de Mexico	Critically Ill\|Cancer	October 2015	Phase 2\|Phase 3
NCT00741663	University of Padova	Cirrhosis\|Ascites	April 2005	Phase 4
NCT01021943	Instituto Nacional de Cardiologia Ignacio Chavez	Kidney Transplant	November 2009	Phase 2
NCT00865449	Instituto Nacional de Cardiologia Ignacio Chavez	End Stage Renal Disease	July 2008	Phase 3
NCT04393493	Hospital Civil de Guadalajara	Cardiorenal Syndrome	July 1, 2017	Phase 2
NCT01059136	Assistance Publique - Hôpitaux de Paris	Myocardial Infarction	February 2010	Phase 3
NCT01089309	Wolfson Medical Center	Arterial Stiffness\|Arterial Elasticity	May 2004	Phase 4
NCT02907749	Changqing Yang\|Shanghai Tongji Hospital, Tongji University School of Medicine	Cirrhosis\|Portal Hypertension	January 1, 2018	Phase 4
NCT00524615	Jan Vaclavík\|Czech Society of Hypertension\|Prostejov Hospital\|Brno University Hospital\|Olomouc Military Hospital\|Gedeon Richter Ltd.\|University Hospital Olomouc	Hypertension	September 2007	Phase 4
NCT01848639	University Hospital, Brest\|Central Hospital, Nancy, France\|Institut National de la Santé Et de la Recherche Médicale, France	End Stage Renal Failure on Dialysis	June 2013	Phase 3
NCT00106561	Melbourne Health	Kidney Disease\|Diabetic Nephropathy\|Glomerulonephritis\|Proteinuria	January 2002	Phase 2\|Phase 3
NCT04331691	Yonsei University	Resistant Hypertension	November 16, 2020	Phase 4
NCT01406015	Brigham and Women´s Hospital	Obesity\|Insulin Resistance	February 2009	Not Applicable
NCT00353652	University of Texas Southwestern Medical Center\|National Heart, Lung, and Blood Institute (NHLBI)	Hypertension	January 2005	Phase 4
NCT03334682	Nantes University Hospital	Acne Vulgaris	January 31, 2018	Phase 3
NCT03867682	Actinium Pharmaceuticals	Acute Myeloid Leukemia\|Relapsed Adult AML	January 15, 2020	Phase 1\|Phase 2
NCT01598740	Sorbent Therapeutics	Heart Failure	June 2012	Phase 1
NCT01069510	Oregon Health and Science University\|National Heart, Lung, and Blood Institute (NHLBI)\|Oregon Clinical and Translational Research Institute	Congenital Heart Disease\|Heart Failure\|Endomyocardial Fibrosis	February 2010	Phase 2
NCT02832973	Sao Jose do Rio Preto Medical School	Hypertension Resistant to Conventional Therapy	September 2015	Phase 4
NCT03597035	University Hospitals Cleveland Medical Center\|Relypsa, Inc.	Type2 Diabetes\|Hyperkalemia	July 17, 2018	Phase 4
NCT03909529	CMP Development, LLC	Drug Drug Interaction	March 10, 2019	Phase 1
NCT04424134	Lomonosov Moscow State University Medical Research and Educational Center	COVID 19	May 16, 2020	Phase 3
NCT02673463	University of Birmingham	Atrial Fibrillation	January 2015	Phase 4
NCT04618601	Laikο General Hospital, Athens	Heart Failure Acute\|Heart Failure; With Decompensation	October 20, 2020	Phase 4
NCT01468571	Baylor College of Medicine\|National Heart, Lung, and Blood Institute (NHLBI)	Pulmonary Hypertension	July 2011	Phase 4
NCT00240656	Hebei Medical University	Hypertension, Pulmonary	October 2005	Phase 1
NCT00332904	Hvidovre University Hospital	Liver Cirrhosis\|Portal Hypertension	August 2006	Phase 4
NCT04522739	Emory University\|Alzheimer´s Association	Mild Cognitive Impairment\|Alzheimer Disease	September 6, 2022	Phase 4
NCT02230891	VA Office of Research and Development\|Baylor College of Medicine	Hypertension\|Diabetes\|Cardiovascular Disease	October 1, 2014	Phase 2
NCT01855334	Brigham and Women´s Hospital\|Massachusetts General Hospital\|Beth Israel Deaconess Medical Center\|Joslin Diabetes Center	End Stage Renal Disease\|Hemodialysis	September 2013	Phase 4
NCT04283656	Thomas Jefferson University	Transgender Health\|Gender Dysphoria\|Transgender Women\|Human Immunodeficiency Virus	February 14, 2022	Phase 1
NCT03314493	Professor Fernando Figueira Integral Medicine Institute\|Federal University of São Paulo	Coronary Artery Calcification\|Vascular Calcification	November 7, 2014	Phase 3
NCT01817803	Yonsei University	Congestive Heart Failure	March 2013	Not Applicable
NCT02046668	University of Dundee\|Arthritis Research UK	Osteoarthritis, Knee	November 2013	Phase 4
NCT01712620	National Institutes of Health Clinical Center (CC)\|National Heart, Lung, and Blood Institute (NHLBI)\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|University of Pennsylvania\|University of Maryland Medical Center\|Medstar Health Research Institute\|New England Medical Center, Tufts University School of Medicine	Pulmonary Arterial Hypertension	January 10, 2014	Phase 2
NCT04643691	Assistance Publique Hopitaux De Marseille	COVID-19\|ARDS	September 11, 2020	Phase 2
NCT03329443	Alhasan Mujtaba Abdul-Wahid\|Ministry of Health-Basra Health Directorate-Al-Sader Teaching Hospital\|University of Baghdad	Acute Kidney Injury\|IHD\|Contrast-induced Nephropathy	September 1, 2017	Phase 2
NCT04901975	Children´s Hospital of Philadelphia\|National Heart, Lung, and Blood Institute (NHLBI)	Single-ventricle	February 11, 2021	Phase 1\|Phase 2
NCT04495712	VA Office of Research and Development	Ventricular Arrhythmias	July 28, 2004	Phase 4
NCT04190433	Mayo Clinic	Lymphoma	September 1, 2020	Phase 2
NCT04100083	Medical University of South Carolina	Hidradenitis Suppurativa	September 21, 2020	Phase 4
NCT00548912	Dawnmarie DeFazio\|West Penn Allegheny Health System	Kidney Failure, Chronic	October 2007	Phase 4
NCT00523757	Justin Ezekowitz\|University of Alberta	Heart Failure	August 2007	Phase 3
NCT03953950	Chiang Mai University	End Stage Renal Disease\|Peritoneal Dialysis	October 2019	Phase 4
NCT01510795	Clinical Hospital Merkur	Kidney Failure, Chronic	January 2012	Phase 4
NCT02426099	Sobngwi Eugene\|University of Yaounde 1\|Yaounde Central Hospital	Hypertension, Resistant to Conventional Therapy\|Diabetes Mellitus	October 2011	Phase 4
NCT03206658	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran\|National Council of Science and Technology, Mexico\|Universidad Nacional Autonoma de Mexico	Acute Kidney Injury	August 1, 2017	Phase 3
NCT02194465	Eli Lilly and Company	Primary Hypertension	August 2014	Phase 2
NCT00295347	Universitätsklinikum Hamburg-Eppendorf	Major Depression	December 2005	Not Applicable
NCT00306696	GlaxoSmithKline	Diabetes Mellitus	October 2002	Phase 4
NCT00528385	Medical University of Gdansk	Chronic Kidney Disease\|Proteinuria	March 2005	Not Applicable
NCT01526616	University Magna Graecia	Polycystic Ovary Syndrome	May 2010	Not Applicable
NCT00224809	Baylor Research Institute\|National Heart, Lung, and Blood Institute (NHLBI)	Cardiovascular Diseases\|Heart Diseases\|Coronary Disease	September 2002	Not Applicable
NCT03777319	Kevin Flanigan\|Muscular Dystrophy Association\|Nationwide Children´s Hospital	Muscular Dystrophy, Duchenne	December 5, 2018	Phase 1
NCT01821703	Eli Lilly and Company	Healthy Volunteers	May 2013	Phase 1
NCT02585843	Columbia University	Heart Failure	November 2015	Phase 2\|Phase 3
NCT05092984	University Hospital, Strasbourg, France	Rheumatoid Arthritis	June 22, 2022	Phase 3
NCT01345656	Bayer	Heart Failure	May 9, 2011	Phase 2
NCT02689843	Shiraz University of Medical Sciences	Polycystic Ovary Syndrome	February 1, 2018	Early Phase 1
NCT01128101	UPECLIN HC FM Botucatu Unesp	Renal Failure	March 2011	Phase 4
NCT00291720	University Hospital Birmingham\|British Heart Foundation	Chronic Kidney Disease\|Cardiovascular Disease	April 2005	Phase 2
NCT01130597	Relypsa, Inc.\|Vifor Pharma	Heart Failure	May 2010	Phase 2
NCT05561361	Second Affiliated Hospital of Nanchang University	Primary Aldosteronism	October 1, 2022
NCT00860340	University of Toledo Health Science Campus\|University of Toledo	Congestive Heart Failure	February 2003	Not Applicable
NCT04455178	Shanghai Jiao Tong University School of Medicine	Hypertension	September 23, 2020	Phase 4
NCT04723862	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Hyperandrogenism\|Polycystic Ovary Syndrome\|Puberty	November 12, 2021	Early Phase 1
NCT02501213	Centre Oscar Lambret\|National Cancer Institute, France	Cancer	May 30, 2016	Phase 2
NCT03576755	University of California, San Francisco	NASH - Nonalcoholic Steatohepatitis	January 9, 2019	Phase 1\|Phase 2
NCT02169089	University Hospitals Cleveland Medical Center\|University of Maryland\|University of Toronto\|Winthrop University	Atherosclerosis	January 2016	Phase 4
NCT02129621	Central Hospital, Nancy, France	Cardiovascular Diseases	May 2010	Not Applicable
NCT00746070	National Taiwan University Hospital	Aldosteronism	January 2007
NCT01422759	University of Virginia	Obesity\|Hyperandrogenemia\|Polycystic Ovary Syndrome	December 9, 2016	Not Applicable
NCT05222191	Indiana Institute for Medical Research	Renal Insufficiency\|Chronic Hypertension	February 1, 2022	Phase 2
NCT01055223	GlaxoSmithKline	Fractures, Bone\|Type II Diabetes	May 2009
NCT03981861	Children´s Mercy Hospital Kansas City	PCOS	July 2, 2016	Phase 2\|Phase 3
NCT01643434	Instituto do Coracao\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Hypertension	August 2012	Phase 4
NCT03502031	James A. Tumlin, MD\|Nelson Kopyt, MD\|NephroNet, Inc.	Renal Insufficiency, Chronic\|Diabetic Nephropathy Type 2	October 1, 2018	Phase 4
NCT03429946	Brigham and Women´s Hospital\|Beth Israel Deaconess Medical Center\|National Heart, Lung, and Blood Institute (NHLBI)	Hypoglycemia\|Healthy	July 17, 2013	Phase 4
NCT00689598	Taichung Veterans General Hospital	Atrial Fibrillation	March 2008	Not Applicable
NCT00879060	Tufts Medical Center	Myocardial Fibrosis\|Hypertrophic Cardiomyopathy	November 2007	Phase 4
NCT00391846	AstraZeneca	Heart Failure\|Ventricular Dysfunction, Left	October 2006	Phase 4
NCT00842140	University of Sao Paulo	Polycystic Ovary Syndrome	February 2006	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL ( 120.03 mM )

H ₂ O : 0.1 mg/mL ( 0.24 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4006 mL	12.0028 mL	24.0056 mL
5 mM	0.4801 mL	2.4006 mL	4.8011 mL
10 mM	0.2401 mL	1.2003 mL	2.4006 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5(3):37-50.
[2] Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285(39):29932-29940.
[3] Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51(4):755-764.

Synonyms

Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-

17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate

Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.

SC 9420

3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone

Aldactone

Aldactone A

17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate

3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone

Spironolactone

Spironolactone A

3′-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone

7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone

Verospiron

7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone

Verospirone

Spiresis

Spiridon

Spirolang

Spirone

Uractone

Spirolactone

Duraspiron

Spiretic

Spiroderm

Altex

Urusonin

Osyrol

Dira

Supra-Puren

Almatol

Spiro-Tablinen

Aquareduct

Aldace

Sagisal

Xenalon

Aldopur

Laractone

Sincomen

Osiren

Suracton

Nefurofan

Lacalmin

Abbolactone

Lacdene

Spirolone

Diatensec

Deverol

Euteberol

Spiroctan

NSC 150399

Quimolactona

Berlactone

Novo-Spiroton

Spironol

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