[CAS NO. 52-21-1] Prednisolone acetate

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PRODUCTS SPECIFICATIONS [52-21-1]

Catalog

HY-B1214

Brand

MCE

CAS

52-21-1

DESCRIPTION [52-21-1]

Overview

MDL	-
Molecular Weight	402.48
Molecular Formula	C23H30O6
SMILES	C[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

For research use only. We do not sell to patients.

Summary

Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01872611	Alcon Research	Non-Proliferative Diabetic Retinopathy\|Cataract	June 2013	Phase 3
NCT00689078	ORA, Inc.	Allergic Conjunctivitis	May 2008	Phase 4
NCT04351737	Brandon Eye Associates, PA	Pterygium of Both Eyes	July 15, 2020	Phase 4
NCT01939691	University of California, San Francisco\|Aravind Eye Hospitals, India	Uveitis\|Macular Edema	September 12, 2018	Phase 4
NCT00782717	Alcon Research	Macular Edema	November 2008	Phase 2
NCT01244334	Edward J. Holland\|Sirion Therapeutics, Inc.\|Alcon Research\|Parsons Medical Communications\|Cincinnati Eye Institute Northern Kentucky	Cataracts\|Corneal Edema\|Retinal Structural Change, Deposit and Degeneration\|Visual Acuity Reduced Transiently	March 2009	Phase 4
NCT02515045	Carolina Eyecare Physicians, LLC\|Science in Vision	Cataract	January 2015	Phase 4
NCT04464629	Midwest Eye Institute\|Ocular Therapeutix, Inc.	Retinal Detachment	July 14, 2020	Phase 4
NCT04479748	Prism Vision Group	Cataract	October 1, 2020	Phase 4
NCT03578276	Carolina Eyecare Physicians, LLC\|Science in Vision\|Imprimis Pharmaceuticals, Inc.	Cataract	June 22, 2018	Phase 4
NCT00501579	Sirion Therapeutics, Inc.	Uveitis		Phase 3
NCT01011621	Mantecorp Industria Quimica e Farmaceutica Ltd.	Dermatitis, Atopic\|Dermatitis, Contact\|Dermatitis, Seborrheic\|Psoriasis	February 2010	Phase 3
NCT04371445	The Cleveland Clinic\|Ocular Therapeutix, Inc.	Vitreoretinal Surgery\|Ocular Inflammation\|Post-operative Pain\|Post-Operative Inflammation	December 1, 2020	Phase 4
NCT04563299	Retina Vitreous Associates of Florida\|Ocular Therapeutix, Inc.	Neovascular Age-related Macular Degeneration\|Diabetic Macular Edema\|Retinal Vein Occlusion	December 9, 2020	Phase 4
NCT00833495	Fovea Pharmaceuticals SA	Allergic Conjunctivitis	January 2009	Phase 2
NCT01853696	Cornea Research Foundation of America	Fuchs´ Dystrophy\|Corneal Edema	March 2013	Phase 4
NCT02517619	Eyegate Pharmaceuticals, Inc.	Anterior Uveitis	January 16, 2016	Phase 3
NCT04403516	Michelle Rhee MD\|Ocular Therapeutix, Inc.\|New York Eye Specialists	Pterygium	October 1, 2020	Phase 4
NCT04977427	Baylor Research Institute	Cataract Diabetic\|Macula Edema	July 2021	Phase 4
NCT01505088	Eyegate Pharmaceuticals, Inc.	Anterior Uveitis	December 2011	Phase 3
NCT00493064	Palo Alto Medical Foundation	Retinal Vein Occlusion	October 2006	Phase 2\|Phase 3
NCT02406209	Aldeyra Therapeutics, Inc.	Non-infectious Anterior Uveitis	March 2015	Phase 2
NCT02412059	Unity Health Toronto\|University of Toronto	Epiretinal Membrane	August 2015	Not Applicable
NCT01853072	Alcon Research	Non-Proliferative Diabetic Retinopathy\|Cataract	June 2013	Phase 3
NCT00758199	Bp Consulting, Inc	Cataracts	July 2008	Phase 4
NCT00433225	Innovative Medical	Macula Thickening		Phase 4
NCT05585346	Beijing Tongren Hospital	Bell´s Palsy	January 1, 2021	Not Applicable
NCT00348244	Innovative Medical	Cataract		Phase 4
NCT00865540	Clinica Oftamologica Zona Sul	Cataract	March 2009	Phase 4
NCT04168112	Sight Medical Doctors PLLC\|Ocular Therapeutix, Inc.	Keratoconus, Unstable\|Collagen Crosslinking\|Postoperative Pain	February 12, 2020	Phase 4
NCT03596723	Kala Pharmaceuticals, Inc.	Ocular Inflammation	July 3, 2018	Phase 3
NCT04563559	Duke University\|Ocular Therapeutix, Inc.	Cataract Surgery\|Glaucoma Surgery	November 2020	Phase 2\|Phase 3
NCT04316936	Silverstein Eye Centers\|Ocular Therapeutix, Inc.	Cataract Surgery	December 10, 2019	Phase 4
NCT04200651	The New York Eye Surgery Center\|Ocular Therapeutix, Inc.	Glaucoma\|Cataract	January 13, 2020	Phase 4
NCT05461261	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	Hormone Sensitive Metastatic Prostate Cancer\|DNA Damage Repair Deficiency\|Chemotherapy Effect\|Chemotherapeutic Toxicity	July 1, 2022	Phase 2
NCT00406042	West Virginia University	Glaucoma	September 2005	Not Applicable
NCT01218737	Federal University of São Paulo\|Allergan	Ocular Infection and Inflammation	January 2009	Phase 3
NCT01124045	Alcon Research	Cataracts\|Inflammation	August 2010	Phase 3
NCT01201798	Alcon Research	Endogenous Anterior Uveitis	October 2010	Phase 3
NCT03415828	Gelscom SAS\|CEISO	Lumbar Discogenic Pain (Disorder)	May 29, 2018	Not Applicable
NCT04863742	Sight Medical Doctors PLLC\|Ocular Therapeutix, Inc.	Dry Eye Syndromes	April 26, 2021	Phase 4
NCT05191706	EyePoint Pharmaceuticals, Inc.	Cataract	January 4, 2022	Phase 4
NCT04521140	Nicole Fram M.D.\|Advanced Vision Care	Corneal Edema\|Corneal Defect\|Corneal Transplant\|Penetrating KeratoPlasty\|Anterior Chamber Inflammation\|Ocular Pain\|Intraocular Pressure	October 16, 2020	Phase 4
NCT04362241	Ophthalmic Consultants of the Capital Region	Retinopathy, Diabetic	August 7, 2020	Phase 4
NCT04631315	Laboratorios Poen	Cataract	March 24, 2019	Phase 4
NCT03123614	University of Utah	Intraocular Pressure\|Corneal Opacity	September 19, 2014	Phase 4
NCT00134992	Novartis	Healthy	August 2004	Phase 4
NCT01437982	Bausch & Lomb Incorporated	Conjunctivitis, Seasonal Allergic\|Conjunctivitis, Giant Papillary\|Inflammation	August 5, 2010	Phase 4
NCT00345046	Indiana University School of Medicine\|Indiana University	Glaucoma\|Cataract	September 2002	Phase 4
NCT04273282	Research Insight LLC	Cataract	December 16, 2019	Phase 4
NCT01482897	Nantes University Hospital	Discal Sciatica	December 2011	Phase 3
NCT04590183	Peking University	Posner Schlossman Syndrome	October 1, 2020	Not Applicable
NCT04184999	SR Cornea Consultants	Dry Eye Syndromes	August 10, 2019	Phase 4
NCT02416128	Larkin Community Hospital\|Nova Southeastern University	Iritis	April 30, 2015	Not Applicable
NCT01448213	Price Vision Group	Fuchs´ Dystrophy\|Bullous Keratopathy	October 2011	Phase 2
NCT05248139	Visualiza\|Seva Foundation	Cataract\|Ocular Inflammation\|Ocular Hypertension\|Post-Op Complication	October 2022	Not Applicable
NCT04426734	New England Retina Associates\|Ocular Therapeutix	Non-infectious Anterior Uveitis	July 1, 2020	Phase 4
NCT00170729	Novartis	Cataract Surgery	August 17, 2004	Phase 4
NCT02309385	Aciont Inc\|National Eye Institute (NEI)	Non-Infectious Anterior Uveitis	October 2014	Phase 1\|Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 124.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4846 mL	12.4230 mL	24.8460 mL
5 mM	0.4969 mL	2.4846 mL	4.9692 mL
10 mM	0.2485 mL	1.2423 mL	2.4846 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 3 mg/mL (7.45 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 3 mg/mL (7.45 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 3 mg/mL (7.45 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)-

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-, 21-acetate

(11β)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione

Meticortelone acetate

Nisolone

Prednisolone 21-acetate

Supercortyl

11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate

Prednisolone acetate

21-Acetoxy-11β,17-dihydroxypregna-1,4-diene-3,20-dione

Prenema

Cormalone

Cortipred

Deltilen

Prediacortin

Predicort

Prednelan N

Prednidoren

Inflanefran Forte

Hydroprednisone acetate

Pred-Forte

21-(Acetoxy)-11β,17α-dihydroxypregna-1,4-diene-3,20-dione

Econopred

Predalone 50

Ak-Tate

Meticotelone acetate

Inflanefran

Pred Mild

NSC 10966

Falcon

Falcon (steroid)

EconoPred Plus

Omnipred