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Catalog: | HY-B0648 |
Brand: | MCE |
CAS: | 520-85-4 |
MDL | - |
---|---|
Molecular Weight | 344.49 |
Molecular Formula | C22H32O3 |
SMILES | C[C@@]1([C@@]2(O)C(C)=O)[C@](CC2)([H])[C@@](C[C@H](C)C3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC1 |
Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. Target: Progesterone Receptor Medroxyprogesterone (MP), is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is an metabolite of MPA [1].
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT00004650 | National Institute of Dental and Craniofacial Research (NIDCR)|Washington University School of Medicine|Office of Rare Diseases (ORD) |
Osteoporosis
|
August 1993 | Phase 3 |
NCT00577122 | Indiana University|Translational Breast Cancer Research Consortium |
Estrogen Receptor-negative Breast Cancer|Progesterone Receptor-negative Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
|
July 2007 | Phase 2 |
NCT00000466 | National Heart, Lung, and Blood Institute (NHLBI)|National Institute on Aging (NIA)|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Bone Diseases|Cardiovascular Diseases|Coronary Disease|Diabetes Mellitus|Heart Diseases|Hypercholesterolemia|Hypertension|Myocardial Ischemia|Osteoporosis|Thrombosis|Postmenopause
|
September 1987 | Phase 3 |
NCT00033358 | National Cancer Institute (NCI) |
Endometrial Cancer
|
February 2002 | Phase 2 |
NCT00016601 | National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
HIV Infections
|
June 2001 | Not Applicable |
NCT01143207 | FHI 360|Eastern Virginia Medical School |
Contraception
|
May 2010 | Not Applicable |
NCT00044837 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Phase 1 | |
NCT05247268 | Fudan University|Peking Union Medical College Hospital |
Endometrial Neoplasm Malignant Stage I
|
March 11, 2022 | Phase 2 |
NCT00319566 | University of California, San Francisco|Wyeth is now a wholly owned subsidiary of Pfizer |
Coronary Heart Disease
|
July 1992 | Phase 3 |
NCT01776203 | Kaiser Permanente |
Dysfunctional Uterine Bleeding
|
January 2012 | Phase 4 |
NCT02228681 | Gynecologic Oncology Group|Novartis Pharmaceuticals|GOG Foundation |
Advanced, Persistent, or Recurrent Endometrial Cancer
|
February 2015 | Phase 2 |
NCT01148420 | Women´s Health Care Clinic, Torrance, California |
Dysfunctional Uterine Bleeding
|
January 2009 | Phase 4 |
NCT00064025 | Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation |
Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
|
April 2004 | Phase 2 |
NCT02509767 | Planned Parenthood Federation of America|Pfizer|Tara Health Foundation |
Contraception
|
August 2015 | Phase 4 |
NCT03018249 | National Cancer Institute (NCI)|NRG Oncology |
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma
|
October 11, 2017 | Early Phase 1 |
NCT00066157 | University of Wisconsin, Madison|National Institute on Aging (NIA) |
Alzheimer Disease
|
September 2001 | Phase 2|Phase 3 |
NCT01791413 | Mahidol University |
Endometriosis
|
March 2012 | Phase 1|Phase 2 |
NCT00360490 | Bayer |
Menorrhagia
|
July 2006 | Phase 3 |
NCT00291369 | Centre Leon Berard|French Immunotherapy Intergroup|SCAPP (Sub-Cutaneous Administration Proleukin Program) |
Metastatic Renal Cell Carcinoma
|
December 1999 | Phase 3 |
NCT00437658 | AbbVie |
Endometriosis
|
December 11, 2006 | Phase 2 |
NCT01822288 | Far Eastern Memorial Hospital |
Menopausal Syndromes
|
November 16, 2012 | Phase 4 |
NCT05565573 | Hua Li|Beijing Chao Yang Hospital |
Fertility Sparing
|
November 1, 2022 | Phase 2|Phase 3 |
NCT00083824 | Tufts University|National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Disease|Heart Diseases|Coronary Arteriosclerosis
|
March 2004 | Phase 2|Phase 3 |
NCT00169299 | Kaiser Permanente|National Institute on Aging (NIA)|National Center for Complementary and Integrative Health (NCCIH) |
Vasomotor Symptoms Associated With Menopause
|
June 2001 | Phase 4 |
NCT02579590 | Assiut University |
Female Sexual Function
|
May 1, 2017 | |
NCT04710017 | Assiut University |
Uterine Bleeding
|
February 1, 2021 | Not Applicable |
NCT00420342 | Bayer |
Postmenopause|Hypertension|Pre-Hypertension
|
January 2007 | Phase 2 |
NCT00828542 | University of Sao Paulo |
Breastfeeding|Contraception
|
July 2007 | Not Applicable |
NCT02894151 | Chulalongkorn University |
Clinically Diagnosed Endometriotic Patient Was Defined as a Woman Who Has Pelvic Pain and at Least One Evidence of PV or TVS
|
April 2015 | Phase 2 |
NCT01019369 | Carolyn L. Westhoff|Family Planning Fellowship|Pfizer|Columbia University |
Contraception
|
March 2010 | Not Applicable |
NCT00997893 | University of Illinois at Chicago|National Institute of Mental Health (NIMH) |
Menopause|Hot Flashes
|
December 2009 | Phase 2 |
NCT03660046 | Emory University|National Institutes of Health (NIH)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Hormonal Contraception
|
December 7, 2018 | |
NCT03097120 | Wake Forest University Health Sciences|National Heart, Lung, and Blood Institute (NHLBI) |
Heart Disease
|
January 1995 | Phase 3 |
NCT03675139 | Xiaojun Chen|Fudan University |
Endometrial Hyperplasia Without Atypia
|
February 26, 2019 | Phase 2|Phase 3 |
NCT01472315 | Turku University Hospital |
Sleep Apnea
|
January 2000 | Phase 2|Phase 3 |
NCT01463202 | Beatrice Chen|Society of Family Planning|University of Pittsburgh |
Contraception|Postpartum Depression|Lactation
|
November 2011 | Phase 4 |
NCT01011751 | Takeda |
Adenocarcinoma, Prostate
|
April 2004 | Phase 3 |
NCT00830414 | Teva Pharmaceuticals USA |
Healthy
|
April 2002 | Phase 1 |
NCT01074892 | University Hospital of North Norway|Helse Nord|Norwegian Cancer Society |
Endometrial Hyperplasia
|
May 2005 | Phase 4 |
NCT01056042 | Prince of Songkla University |
Endometriosis
|
June 2007 | Phase 4 |
NCT00332553 | Eli Lilly and Company |
Vasomotor Symptoms|Endometrial Safety
|
February 2002 | Phase 2 |
NCT00000559 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause
|
March 1995 | Phase 3 |
NCT02103764 | Mahidol University |
Dysfunctional Uterine Bleeding
|
August 2013 | Phase 3 |
NCT00743574 | Yale University|National Center for Research Resources (NCRR) |
Polycystic Ovarian Syndrome|Vitamin D Deficiency
|
August 2008 | Not Applicable |
NCT03309176 | Radboud University Medical Center |
Ovulation Disorder
|
June 21, 2016 | Phase 4 |
NCT04669678 | University of Washington|Merck Sharp & Dohme LLC|Wits Reproductive Health and HIV Institute |
HIV Infections|Contraception|Drug-drug Interaction
|
November 17, 2021 | |
NCT00416429 | Centre Leon Berard |
Kidney Cancer
|
Phase 3 | |
NCT04910711 | Botswana Harvard AIDS Institute Partnership|University of Liverpool |
Human Immunodeficiency Virus|Contraception|ART
|
October 21, 2021 | Phase 4 |
NCT05491343 | HaEmek Medical Center, Israel |
Arteriovenous Malformations
|
August 2022 | Phase 4 |
NCT01461824 | Nationwide Children´s Hospital|Society of Family Planning |
Weight Gain|Disorder of Bone Density and Structure, Unspecified|Uterine Bleeding
|
September 2011 | Phase 3 |
NCT00191113 | Eli Lilly and Company |
Turner Syndrome
|
February 1989 | Phase 3 |
NCT02272647 | Mayo Clinic |
Healthy
|
December 2014 | Phase 1 |
NCT00006133 | National Center for Research Resources (NCRR)|University of Alabama at Birmingham |
Systemic Lupus Erythematosus
|
June 2000 | Not Applicable |
NCT05255653 | Leiden University Medical Center|Institute Gustave Roussy (sponsor p53abn-RED trial)|Leiden University Medical center (sponsor MMRd-GREEN trial)|University College London (sponsor NSMP-ORANGE trial)|Canadian Clinical Trials Group (sponsor POLEmut-BLUE trial)|Dutch Gynaecological Oncology Group|Comprehensive Cancer Centre The Netherlands|Cancer Research UK & UCL Cancer Trials Centre|Dutch Cancer Society|AstraZeneca |
Endometrial Cancer
|
November 11, 2021 | Phase 2|Phase 3 |
NCT02357368 | Lisa Haddad|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Emory University |
HIV|Contraception
|
February 2015 | Phase 4 |
NCT02412436 | AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV-1 Infection|Tuberculosis
|
November 3, 2015 | Phase 2 |
NCT00030914 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Hot Flashes
|
April 2002 | Phase 3 |
NCT02872818 | Kayseri Education and Research Hospital |
Apoptotic Signal Pathways in Endometrial Hyperplasia
|
October 2014 | Phase 4 |
NCT04654741 | Casa di Cura Privata Villa Mafalda |
IVF|Infertility
|
September 1, 2020 | Phase 4 |
NCT00739830 | Merck Sharp & Dohme LLC |
Endometrial Cancer
|
August 2008 | Phase 2 |
NCT00002920 | Southwest Oncology Group|National Cancer Institute (NCI)|Cancer and Leukemia Group B |
Breast Cancer|Endometrial Cancer
|
March 1997 | Phase 3 |
NCT00026286 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI) |
Breast Cancer|Hot Flashes|Menopausal Symptoms
|
September 2000 | Phase 3 |
NCT04997811 | Prof. Janet Dunn|Blood Cancer UK|Dudley Group NHS Foundation Trust|University of Birmingham|University of Manchester|King´s College Hospital NHS Trust|University of Warwick |
Myelodysplastic Syndromes (MDS)
|
December 21, 2021 | Phase 2 |
NCT02943655 | Assiut University |
Improve Quality of Life|Heavy Menstrual Bleeding
|
November 1, 2017 | Phase 3 |
NCT00006324 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
December 1999 | Not Applicable |
NCT02340013 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital|University of Toronto |
Infertility
|
July 2013 | Phase 4 |
NCT00091728 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Chlamydia Infection|Neisseriaceae Infection
|
September 1997 | |
NCT02335203 | Women and Infants Hospital of Rhode Island |
Grade 1 Endometrial Endometrioid Adenocarcinoma|Grade 2 Endometrial Endometrioid Adenocarcinoma|Complex Atypical Endometrial Hyperplasia
|
February 2015 | Phase 2 |
NCT00000605 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Arteriosclerosis|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause
|
August 1996 | Phase 3 |
NCT01191203 | Emory University|University of North Carolina|National Institute of Allergy and Infectious Diseases (NIAID) |
HIV
|
July 2010 | Not Applicable |
NCT00003179 | Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation |
Endometrial Cancer
|
November 1998 | Phase 2 |
NCT02122198 | University of Colorado, Denver |
Cognitive Impairment|Executive Dysfunction|Endothelial Dysfunction|Cardiovascular Disease
|
September 8, 2014 | Not Applicable |
NCT00808132 | Pfizer |
Menopause|Osteoporosis
|
January 2009 | Phase 3 |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 50 mg/mL ( 145.14 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.9028 mL | 14.5142 mL | 29.0284 mL |
5 mM | 0.5806 mL | 2.9028 mL | 5.8057 mL |
10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL |
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution
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