[CAS NO. 521-34-6] Sciadopitysin
PRODUCTS SPECIFICATIONS [521-34-6]
DESCRIPTION [521-34-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 580.54 |
| Molecular Formula | C33H24O10 |
| SMILES | O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(OC)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13 |
Summary
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba [1] . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 [2] .
IC50 & Target
|
NF-κB |
In Vitro
Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1 [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 20 mg/mL ( 34.45 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7225 mL | 8.6127 mL | 17.2253 mL |
| 5 mM | 0.3445 mL | 1.7225 mL | 3.4451 mL |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7225 mL |
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1.
References
- [1] Briançon-Scheid F, et al. HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. Planta Med. 1983 Dec;49(12):204-7.
- [2] Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents boneloss in LPS-treated mice. Int Immunopharmacol. 2017 Aug;49:109-117.
Synonyms