[CAS NO. 521937-07-5] CID755673

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PRODUCTS SPECIFICATIONS [521937-07-5]

Catalog

HY-12239

Brand

MCE

CAS

521937-07-5

DESCRIPTION [521937-07-5]

Overview

MDL	MFCD03828155
Molecular Weight	217.22
Molecular Formula	C12H11NO3
SMILES	O=C1NCCCC2=C1OC3=CC=C(O)C=C32

For research use only. We do not sell to patients.

7 Publications Citing Use of MCE

Summary

CID755673 is a potent PKD inhibitor with IC ₅₀ s of 182 nM, 280 nM and 227 nM for PKD1 , PKD2 and PKD3 , respectively.

IC50 & Target

PKD1

182 nM (IC ₅₀ )

PKD3

227 nM (IC ₅₀ )

PKD2

280 nM (IC ₅₀ )

In Vitro

CID755673 blocks phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibits the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation. CID755673 inhibits prostate cancer cell proliferation, cell migration, and invasion ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acute administration of the PKD inhibitor CID755673 to normal mice reduces both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduces expression of the gene expression signature of PKD activation, enhances indices of both diastolic and systolic left ventricular function and is associated with reduced heart weight ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 460.36 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6036 mL	23.0181 mL	46.0363 mL
5 mM	0.9207 mL	4.6036 mL	9.2073 mL
10 mM	0.4604 mL	2.3018 mL	4.6036 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution

* All of the co-solvents are available by MCE.