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[CAS NO. 521937-07-5] CID755673
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-12239 |
| Brand: | MCE |
| CAS: | 521937-07-5 |
Overview
| MDL | MFCD03828155 |
|---|---|
| Molecular Weight | 217.22 |
| Molecular Formula | C12H11NO3 |
| SMILES | O=C1NCCCC2=C1OC3=CC=C(O)C=C32 |
7 Publications Citing Use of MCE
- [1]Brain Res Bull. 2020 Sep;162:141-150.
- [2]Biochem Biophys Res Commun. 2022.
- [3]Biochem Biophys Res Commun. 2020 Apr 2;524(2):280-287.
- [4]Exp Ther Med. 2019 Apr;17(4):2511-2518.
- [5]Int J Clin Exp Med. 2017;10(7):10528-10534.
- [6]Chinese Journal of Pathophysiology. 2016, 32(1):146-150, 155.
- [7]Harvard Medical School LINCS LIBRARY
Summary
IC50 & Target
|
PKD1 182 nM (IC 50 ) |
PKD3 227 nM (IC 50 ) |
PKD2 280 nM (IC 50 ) |
In Vitro
CID755673 blocks phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibits the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation. CID755673 inhibits prostate cancer cell proliferation, cell migration, and invasion [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Acute administration of the PKD inhibitor CID755673 to normal mice reduces both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduces expression of the gene expression signature of PKD activation, enhances indices of both diastolic and systolic left ventricular function and is associated with reduced heart weight [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 460.36 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6036 mL | 23.0181 mL | 46.0363 mL |
| 5 mM | 0.9207 mL | 4.6036 mL | 9.2073 mL |
| 10 mM | 0.4604 mL | 2.3018 mL | 4.6036 mL |
References
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