[CAS NO. 52248-03-0]  S-Adenosyl-L-methionine tosylate

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PRODUCTS SPECIFICATIONS [52248-03-0]

Catalog
HY-B0617A
Brand
MCE
CAS
52248-03-0

DESCRIPTION [52248-03-0]

Overview

MDLMFCD00063498
Molecular Weight570.64
Molecular FormulaC22H30N6O8S2
SMILESO[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3C[S+](CC[C@H](N)C(O)=O)C.O=S(C4=CC=C(C)C=C4)([O-])=O

For research use only. We do not sell to patients.


Summary

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research [1] [2] [3] .


IC50 & Target

Human Endogenous Metabolite


In Vitro

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine [2] .
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00513461 Chao Family Comprehensive Cancer Center|National Cancer Institute (NCI)|University of California, Irvine
Adult Primary Liver Cancer|Hepatitis C Infection
October 2007 Phase 2
NCT00722124 Mayo Clinic|Pharmavite LLC
Tobacco Dependence
September 2008 Phase 2|Phase 3
NCT03178929 Beijing Insight Science & Technology Co. Ltd.
Primary Liver Cancer
July 1, 2017 Not Applicable

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)


Solvent & Solubility

In Vitro:

H 2 O : 150 mg/mL ( 262.86 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7524 mL 8.7621 mL 17.5242 mL
5 mM 0.3505 mL 1.7524 mL 3.5048 mL
10 mM 0.1752 mL 0.8762 mL 1.7524 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (175.24 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.