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[CAS NO. 52549-17-4] Pranoprofen
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0336 |
| Brand: | MCE |
| CAS: | 52549-17-4 |
Overview
| MDL | MFCD00866111 |
|---|---|
| Molecular Weight | 255.27 |
| Molecular Formula | C15H13NO3 |
| SMILES | CC(C(O)=O)C1=CC2=C(C=C1)OC3=NC=CC=C3C2 |
Summary
IC50 & Target
|
COX-1
|
COX-2
|
In Vitro
Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells
[1]
.
Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice
[3]
.
Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | DSS-induced acute colitis in C57BL/6 mice [3] |
| Dosage: | 4 mg/kg;16 mg/kg |
| Administration: | Oral administration; 4 mg/kg/16 mg/kg; 9 days |
| Result: | Alleviated inflammation in DSS-induced acute colitis. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03355638 | Università degli Studi di Brescia |
Macular Edema
|
January 2016 | Phase 4 |
| NCT03013959 | Peking Union Medical College |
Keratitis, Herpetic
|
November 2016 | |
| NCT03712670 | Università degli Studi di Brescia |
Retinal Disease
|
January 1, 2016 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 391.74 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9174 mL | 19.5871 mL | 39.1742 mL |
| 5 mM | 0.7835 mL | 3.9174 mL | 7.8348 mL |
| 10 mM | 0.3917 mL | 1.9587 mL | 3.9174 mL |
References
- [1] Toru Hosoi, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54(1):1-6.
- [2] Minting Chen, et al. The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns. J Ophthalmol. 2020 Apr 6;2020:7485912.
- [3] Xiaoli Wu,et al. Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis. Theranostics. 2020 Apr 27;10(13):5749-5762.
Synonyms
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