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[CAS NO. 52665-69-7] Calcimycin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N6687 |
| Brand: | MCE |
| CAS: | 52665-69-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 523.62 |
| Molecular Formula | C29H37N3O6 |
| SMILES | O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC=C1NC)O |
7 Publications Citing Use of MCE
Summary
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis [1] [2] [3] [4] .
In Vitro
Calcimycin (A-23187) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Calcimycin (A-23187) (2.5 or 7.5 nM; intrapleurally) induces protein leakage [5] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Mice (ICR, 25-30 g) [5] |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02992665 | Assiut University |
In Vitro Fertilization|Male Factor Infertility
|
December 2016 | Phase 2|Phase 3 |
| NCT04744753 | MOHAMED BEHERY|Al-Azhar University |
Infertility Primary
|
July 15, 2017 | Phase 4 |
Appearance
Solid
Source
Streptomyces chartreusensis
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33.33 mg/mL ( 63.65 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9098 mL | 9.5489 mL | 19.0978 mL |
| 5 mM | 0.3820 mL | 1.9098 mL | 3.8196 mL |
| 10 mM | 0.1910 mL | 0.9549 mL | 1.9098 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.77 mM); Clear solution
References
- [1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82.
- [2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94.
- [3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90.
- [4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200.
- [5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5.
Synonyms
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