[CAS NO. 53177-12-1] Manganese(salen) chloride
PRODUCTS SPECIFICATIONS [53177-12-1]
DESCRIPTION [53177-12-1]
Overview
| MDL | MFCD00933789 |
|---|---|
| Molecular Weight | 356.69 |
| Molecular Formula | C16H14ClMnN2O2 |
| SMILES | [Cl-][Mn+3]123[O-]C4=C(C=[N]1CC[N]2=CC5=C([O-]3)C=CC=C5)C=CC=C4 |
Summary
In Vitro
Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Wild-type (WT) and harlequin (Hq) B6CBA male and female mice [3] |
| Dosage: | 25 mg/kg/day |
| Administration: | I.p. 3 times a week for 4 weeks |
| Result: |
Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 8.33 mg/mL ( 23.35 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8036 mL | 14.0178 mL | 28.0355 mL |
| 5 mM | 0.5607 mL | 2.8036 mL | 5.6071 mL |
| 10 mM | 0.2804 mL | 1.4018 mL | 2.8036 mL |
References
- [1] Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.
- [2] Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6.
- [3] Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32.