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Catalog: | HY-N0828 |
Brand: | MCE |
CAS: | 537-42-8 |
MDL | MFCD00238710 |
---|---|
Molecular Weight | 256.30 |
Molecular Formula | C16H16O3 |
SMILES | OC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1 |
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium [1] . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties [1] [4] . Pterostilbene blocks ROS production [3] , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide [4] .
Pterostilbene (0, 5, 25, 50, 100, 200 and 400 µM) shows inhibitory activity against the growth of HeLa cells, with IC
50
s of 101.2 µM and 65.9 µM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 µM) also induces the apoptosis HeLa cells
[2]
.
Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe
2+
. Pterostilbene also inhibits single strand breaks in pBR322
[4]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Pterostilbene (30 mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT03635411 | Elysium Health|University of Pennsylvania |
Recovery of Function
|
December 6, 2018 | Phase 1 |
NCT03671811 | City of Hope Medical Center|National Cancer Institute (NCI) |
Atypical Endometrial Hyperplasia|Endometrial Carcinoma
|
January 21, 2019 | Phase 2 |
NCT01267227 | University of Mississippi Medical Center |
Hyperlipidemia|Blood Pressure|Oxidative Stress
|
December 2010 | Phase 2|Phase 3 |
NCT04342975 | Mayo Clinic|Elysium Health |
AKI
|
December 1, 2020 | Phase 2 |
NCT05561075 | Fundació Eurecat|Circe, S.L. |
Biological Availability
|
October 2022 | Not Applicable |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 110 mg/mL ( 429.18 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.9017 mL | 19.5084 mL | 39.0168 mL |
5 mM | 0.7803 mL | 3.9017 mL | 7.8034 mL |
10 mM | 0.3902 mL | 1.9508 mL | 3.9017 mL |
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