[CAS NO. 53797-35-6] Ribostamycin sulfate
PRODUCTS SPECIFICATIONS [53797-35-6]
DESCRIPTION [53797-35-6]
Overview
| MDL | MFCD23380549 |
|---|---|
| Molecular Weight | 552.55 |
| Molecular Formula | C17H36N4O14S |
| SMILES | O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O |
1 Publications Citing Use of MCE
Summary
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies
In Vitro
Ribostamycin is as an intermediate in the biosynthesis of neomycin
[1]
.
Ribostamycin inhibited the chaperone activity of protein disulfide isomerase (PDI), but it did not inhibit the isomerase activity
[3]
.
Ribostamycin is effective against both gram-positive and gram-negative cocci and bacilli including drug-resistant strains. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Streptomyces ribosidicus
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H 2 O : 130 mg/mL ( 235.27 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8098 mL | 9.0490 mL | 18.0979 mL |
| 5 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL |
| 10 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (90.49 mM); Clear solution; Need ultrasonic
References
- [1] Baud H, et al. Ribostamycin, as an intermediate in the biosynthesis of neomycin. J Antibiot (Tokyo). 1977 Sep;30(9):720-3.
- [2] Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.
- [3] Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72.
Synonyms