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[CAS NO. 54-42-2] Idoxuridine
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-B0307 |
| Brand: | MCE |
| CAS: | 54-42-2 |
Overview
| MDL | MFCD00134656 |
|---|---|
| Molecular Weight | 354.10 |
| Molecular Formula | C9H11IN2O5 |
| SMILES | O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(I)C1=O |
1 Publications Citing Use of MCE
Summary
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases . Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC 50 value of 4.3 μM [1] . Idoxuridine shows anti-orthopoxvirus activity.
IC50 & Target
|
HSV-1
|
In Vitro
Idoxuridine (2-10 μM, 72 hours) has the IC
50
value of 4.3 μM of antiviral
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Crandell-Reese feline kidney (CRFK) cells |
| Concentration: | 2-10 μM |
| Incubation Time: | 72 hours |
| Result: | Showed the IC 50 value of 4.3 μM. |
Cell Cytotoxicity Assay [1]
| Cell Line: | Crandell-Reese feline kidney (CRFK) cells |
| Concentration: | 5-50 μM |
| Incubation Time: | 72 hours |
| Result: | Reduced by 10.8% relatively in CRFK cells. |
In Vivo
Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months [2] |
| Dosage: | 50-200 mg/kg |
| Administration: | Intraperitoneal injection, 3 times, 3 hours interval |
| Result: | Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00003405 | Rush University Medical Center|National Cancer Institute (NCI) |
Leukemia
|
April 1998 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 353.01 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8241 mL | 14.1203 mL | 28.2406 mL |
| 5 mM | 0.5648 mL | 2.8241 mL | 5.6481 mL |
| 10 mM | 0.2824 mL | 1.4120 mL | 2.8241 mL |
References
- [1] David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403.
- [2] D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35(1):88-92.
- [3] Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord
Synonyms
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