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[CAS NO. 54143-55-4] Flecainide
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-W010950 |
| Brand: | MCE |
| CAS: | 54143-55-4 |
Overview
| MDL | MFCD00864713 |
|---|---|
| Molecular Weight | 414.34 |
| Molecular Formula | C17H20F6N2O3 |
| SMILES | O=C(C1=CC(OCC(F)(F)F)=CC=C1OCC(F)(F)F)NCC2NCCCC2 |
Summary
Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na + current (INa) and the rapid component of the delayed rectifier K + current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias [1] [2] [3] .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03539302 | InCarda Therapeutics, Inc. |
Paroxysmal Atrial Fibrillation (PAF)
|
May 29, 2018 | Phase 2 |
| NCT00000526 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Coronary Disease|Death, Sudden, Cardiac|Heart Arrest|Heart Diseases|Myocardial Infarction|Myocardial Ischemia|Ventricular Arrhythmia
|
August 1986 | Phase 3 |
| NCT05213104 | Assistance Publique - Hôpitaux de Paris|Fonds de Dotation ACTION |
Patent Foramen Ovale|Atrial Fibrillation|Cryptogenic Stroke
|
March 23, 2022 | Phase 3 |
| NCT00002996 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI) |
Pain
|
February 1998 | Phase 2 |
| NCT03162120 | Elpen Pharmaceutical Co. Inc. |
Atrial Fibrillation|Recurrence
|
September 1, 2018 | Phase 2|Phase 3 |
| NCT02248753 | Maastricht University Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development |
Atrial Fibrillation
|
October 2014 | Not Applicable |
| NCT05549752 | Hippocration General Hospital|Win Medica|Pharmassist Ltd |
Atrial Fibrillation Paroxysmal|Coronary Artery Disease Without Residual Ischemia
|
October 1, 2022 | Phase 3 |
| NCT03005366 | David Filgueiras-Rama|Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III|Hospital San Carlos, Madrid |
Paroxysmal Atrial Fibrillation
|
January 2017 | Phase 4 |
| NCT02347111 | University of Illinois at Chicago|Medtronic |
Atrial Fibrillation
|
December 31, 2020 | Phase 4 |
| NCT03685149 | Wojciech Zareba|University of Rochester |
Arrhythmogenic Right Ventricular Cardiomyopathy
|
July 31, 2019 | Phase 2 |
| NCT02624765 | Edgar Jaeggi|Canadian Institutes of Health Research (CIHR)|St George´s, University of London|The Hospital for Sick Children |
Fetal Atrial Flutter Without Hydrops|Fetal Supraventricular Tachycardia Without Hydrops|Fetal Supraventricular Tachycardia With Hydrops
|
February 2016 | Phase 3 |
| NCT04837261 | Tampere University Hospital|Helsinki University Central Hospital|Kuopio University Hospital|Oulu University Hospital|Turku University Hospital |
Supraventricular Tachycardia
|
April 15, 2021 | |
| NCT00523978 | Medtronic Cardiac Rhythm and Heart Failure|Medtronic |
Paroxysmal Atrial Fibrillation
|
October 2006 | Phase 3 |
| NCT02294955 | Uppsala University Hospital|Swedish Heart Lung Foundation |
Atrial Fibrillation|Quality of Life
|
May 2008 | Not Applicable |
| NCT00215774 | Atrial Fibrillation Network|German Federal Ministry of Education and Research|Meda Pharmaceuticals|German Research Foundation |
Atrial Fibrillation
|
March 2005 | Not Applicable |
| NCT00000556 | National Heart, Lung, and Blood Institute (NHLBI) |
Arrhythmia|Atrial Fibrillation|Cardiovascular Diseases|Heart Diseases
|
March 1995 | Phase 3 |
| NCT03845010 | Maatschap Cardiologie Zwolle |
Ventricular Premature Beats
|
February 12, 2019 | Not Applicable |
| NCT04991896 | AHEPA University Hospital|Skylitseio General Hospital |
Atrial Fibrillation|Arrhythmias, Cardiac
|
January 1, 2020 | |
| NCT01117454 | Vanderbilt University Medical Center |
Catecholaminergic Polymorphic Ventricular Tachycardia
|
December 2011 | Not Applicable |
| NCT00702117 | Hospital Clinic of Barcelona |
Atrial Fibrillation|Tachycardia, Ventricular|Brugada Syndrome
|
June 2008 | Phase 4 |
| NCT03587558 | Keimyung University Dongsan Medical Center|Chong Kun Dang Pharmaceutical Corp. |
Ventricular Premature Complexes|Outflow Tract|Carvedilol
|
September 5, 2017 | Phase 4 |
| NCT00189319 | MEDA Pharma GmbH & Co. KG|Viatris Inc. |
Atrial Fibrillation
|
September 2003 | Phase 4 |
| NCT00408473 | MEDA Pharma GmbH & Co. KG|3M|Viatris Inc. |
Atrial Fibrillation
|
Phase 4 | |
| NCT00000504 | National Heart, Lung, and Blood Institute (NHLBI) |
Arrhythmia|Cardiovascular Diseases|Heart Diseases|Ventricular Arrhythmia
|
September 1982 | Phase 2 |
| NCT01833455 | University of Wisconsin, Madison |
Ventricular Premature Complexes|Blood Pressure
|
February 2013 | Phase 2 |
| NCT01646281 | Maastricht University Medical Center |
Atrial Fibrillation
|
August 2012 | Phase 4 |
| NCT02110537 | Kyunghee University Medical Center|Ministry of Health & Welfare, Korea |
Persistent Atrial Fibrillation
|
March 2014 | Not Applicable |
| NCT02302274 | NYU Langone Health |
Brugada Syndrome|Arrhythmogenic Right Ventricular Cardiomyopathy
|
July 1, 2010 | |
| NCT00392106 | ProRhythm, Inc. |
Atrial Fibrillation
|
April 2006 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 241.35 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4135 mL | 12.0674 mL | 24.1348 mL |
| 5 mM | 0.4827 mL | 2.4135 mL | 4.8270 mL |
| 10 mM | 0.2413 mL | 1.2067 mL | 2.4135 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution
References
- [1] Echt DS, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991 Mar 21;324(12):781-8.
- [2] Aliot E, et al. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73.
- [3] Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8.
Synonyms
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